s Right Drug, Right Dose, Right Time, Right Duration for Every Patient ANTIBIOTICS: DON’T TAKE IT EASY!!! Manas Agrawal*,, Juilee Surve, Dr. Ujwal Kolhe Poona College of Pharmacy, Erandwane, Pune-411038. manas994@gmail.com Right Drug, Right Dose, Right Time, Right Duration for Every Patient What should the prescribers refer while prescribing antibiotics? WHO Guidelines CDC Guidelines FDA Guidelines Attending regular seminars and meetings related to the same Official references ( Physician Desk Reference ) SELF MEDICATION!!! How to ensure proper use of antibiotic? Prescribing generic name instead of particular brand for better understanding and interpretation of antibiotic by the pharmacist Stop date / Review date of the antibiotic therapy must be mentioned on the prescription Antibiotic restriction policy must be followed Dosage regimen should be given utmost importance Narrow spectrum treatment should be preffered OVER PRESCRIBING OF BROAD SPECTRUM ANTIBIOTICS: It is been observed now a days that many RMPs on improper diagnosing prescribe some broad spectrum antibiotic instead of going for specific medication. This may lead to adverse drug effects or other complications, especially resistance for that bacteria. Patient medical report indicating review date. Antibiotic Resistance!!!! The biggest threat to antibiotic treatment is development of bacterial resistance. As per a report of CDC (Centre for Disease Control) every year in USA 20 lac people get affected by bacterial infection of which 23000 die due to development of bacterial resistance ! Antibiotic restriction policies play an important role in prevention of this threat. Graph 1 indicates the rise in development of resistance of S. pneumoneae against the floroquinolone antibiotics through 10 years. Graph 1.Resistance to the antibiotic used: Fluoroquinolones and S. pneumoniae in Canada Case studies Amoxicillin in dental problems. As per WHO guidelines Amoxicillin is strictly to be prescribed if the infection is confirmed due to bacteria, which is not being followed and indiscriminate use of it in dental cases are observed. As per a survey of 366 dental prescriptions made in Brazil, it was observed that only 12 prescriptions were correctly prescribed and common errors were incorrect generic name (21), incorrect dosage regimen(72), discordance of length of antibiotic use(72). Only 91 prescriptions responded to prophylactic use. Only 71 patients continued the treatment after 1st dose. Thus, remaining patients were given the antibiotic irrationally. Cefixime: It is indiscriminately prescribed for RTIs which can be prevented by using normal anti tussives or expectorrants. Undue prescribing of cefixime for dengue like symptoms is been observed. Following are few examples of inappropriate prescribing of antibiotics (as per data collected from different medical stores) Cefadroxil - infections. Cefpodoxime -RTIs. Cefuroxine -pyrexia. Ofloxacin -stomach ache. In this prescription the dosage of amoxicillin is mentioned wrong and is prescribed unnecessarily as the cause was not due to bacteria. General dosage: 200 to 400 mg for 7 to 14 days in 2 divided doses. Conclusion: Judicious selection and use of antibiotics is not only safe and effective but also can prevent development of microbial resistance. References: 1.Hamzeh et. al, American Journal of Infection Control 40 (2012), 776-7. 2. A Webber training telecast by Dr. Mark Thomas on antibiotic restriction policies, Fluroquinolone resistance. 3. Lisboa et. al, Amoxicillin dntal case study, American Journal of Infection Control 43 (2015), 766-8. 4. C.I.M.S 36th year, Jan to April 2015. NATIONAL PHARMACY WEEK 2015-16

s Right Drug, Right Dose, Right Time, Right Duration for Every Patient ANTIBIOTICS: DON’T TAKE IT EASY!!! Manas Agrawal*, Ketan Kulkarni, Juilee Surve, Dr. Ujwal Kolhe Poona College of Pharmacy, Erandwane, Pune-411038. manas994@gmail.com Right Drug, Right Dose, Right Time, Right Duration for Every Patient What should the prescribers refer while prescribing antibiotics? WHO Guidelines CDC Guidelines FDA Guidelines Attending regular seminars and meetings related to the same Official references ( Physician Desk Reference ) SELF MEDICATION!!! How to ensure proper use of antibiotic? Prescribing generic name instead of particular brand for better understanding and interpretation of antibiotic by the pharmacist Stop date / Review date of the antibiotic therapy must be mentioned on the prescription Antibiotic restriction policy must be followed Dosage regimen should be given utmost importance Narrow spectrum treatment should be preffered OVER PRESCRIBING OF BROAD SPECTRUM ANTIBIOTICS: It is been observed now a days that many RMPs on improper diagnosing prescribe some broad spectrum antibiotic instead of going for specific medication. This may lead to adverse drug effects or other complications, especially resistance for that bacteria. Patient medical report indicating review date. Antibiotic Resistance!!!! The biggest threat to antibiotic treatment is development of bacterial resistance. As per a report of CDC (Centre for Disease Control) every year in USA 20 lac people get affected by bacterial infection of which 23000 die due to development of bacterial resistance ! Antibiotic restriction policies play an important role in prevention of this threat. Graph 1 indicates the rise in development of resistance of S. pneumoneae against the floroquinolone antibiotics through 10 years. Graph 1.Resistance to the antibiotic used: Fluoroquinolone Antibiotics and S. pneumoniae in Canada Case studies Amoxicillin in dental problems. As per WHO guidelines Amoxicillin is strictly to be prescribed if the infection is confirmed due to bacteria, which is not being followed and indiscriminate use of it in dental cases are observed. As per a survey of 366 dental prescriptions made in Brazil, it was observed that only 12 prescriptions were correctly prescribed and common errors were incorrect generic name (21), incorrect dosage regimen(72), discordance of length of antibiotic use(72). Only 91 prescriptions responded to prophylactic use. Only 71 patients continued the treatment after 1st dose. Thus, remaining patients were given the antibiotic irrationally. Cefixime: It is indiscriminately prescribed for RTIs which can be prevented by using normal anti tussives or expectorrants. Undue prescribing of cefixime for dengue like symptoms is been observed. Following are few examples of inappropriate prescribing of antibiotics (as per data collected from different medical stores) Cefadroxil - infections. Cefpodoxime -RTIs. Cefuroxine -pyrexia. Ofloxacin -stomach ache. In this prescription the dosage of amoxicillin is mentioned wrong and is prescribed unnecessarily as the cause was not due to bacteria. General dosage: 200 to 400 mg for 7 to 14 days in 2 divided doses. Conclusion: Judicious selection and use of antibiotics is not only safe and effective but also can prevent development of microbial resistance. References: 1.Hamzeh et. al, American Journal of Infection Control 40 (2012), 776-7. 2. A Webber training telecast by Dr. Mark Thomas on antibiotic restriction policies, Fluroquinolone resistance. 3. Lisboa et. al, Amoxicillin dntal case study, American Journal of Infection Control 43 (2015), 766-8. 4. C.I.M.S 36th year, Jan to April 2015. Techmanthan 2016

s Right Drug, Right Dose, Right Time, Right Duration for Every Patient ANTIBIOTICS: DON’T TAKE IT EASY!!! Manas Agrawal*, Apoorva Kulkarni, Dr. Ujwal Kolhe Poona College of Pharmacy, Erandwane, Pune-411038. manas994@gmail.com Right Drug, Right Dose, Right Time, Right Duration for Every Patient What should the prescribers refer while prescribing antibiotics? WHO Guidelines CDC Guidelines FDA Guidelines Attending regular seminars and meetings related to the same Official references ( Physician Desk Reference ) SELF MEDICATION!!! How to ensure proper use of antibiotic? Prescribing generic name instead of particular brand for better understanding and interpretation of antibiotic by the pharmacist Stop date / Review date of the antibiotic therapy must be mentioned on the prescription Antibiotic restriction policy must be followed Dosage regimen should be given utmost importance Narrow spectrum treatment should be preffered OVER PRESCRIBING OF BROAD SPECTRUM ANTIBIOTICS: It is been observed now a days that many RMPs on improper diagnosing prescribe some broad spectrum antibiotic instead of going for specific medication. This may lead to adverse drug effects or other complications, especially resistance for that bacteria. Patient medical report indicating review date. Antibiotic Resistance!!!! The biggest threat to antibiotic treatment is development of bacterial resistance. As per a report of CDC (Centre for Disease Control) every year in USA 20 lac people get affected by bacterial infection of which 23000 die due to development of bacterial resistance ! Antibiotic restriction policies play an important role in prevention of this threat. Graph 1 indicates the rise in development of resistance of S. pneumoneae against the floroquinolone antibiotics through 10 years. Graph 1.Resistance to the antibiotic used: Fluoroquinolone Antibiotics and S. pneumoniae in Canada Case studies Amoxicillin in dental problems. As per WHO guidelines Amoxicillin is strictly to be prescribed if the infection is confirmed due to bacteria, which is not being followed and indiscriminate use of it in dental cases are observed. As per a survey of 366 dental prescriptions made in Brazil, it was observed that only 12 prescriptions were correctly prescribed and common errors were incorrect generic name (21), incorrect dosage regimen(72), discordance of length of antibiotic use(72). Only 91 prescriptions responded to prophylactic use. Only 71 patients continued the treatment after 1st dose. Thus, remaining patients were given the antibiotic irrationally. Cefixime: It is indiscriminately prescribed for RTIs which can be prevented by using normal anti tussives or expectorrants. Undue prescribing of cefixime for dengue like symptoms is been observed. Following are few examples of inappropriate prescribing of antibiotics (as per data collected from different medical stores) Cefadroxil - infections. Cefpodoxime -RTIs. Cefuroxine -pyrexia. Ofloxacin -stomach ache. In this prescription the dosage of amoxicillin is mentioned wrong and is prescribed unnecessarily as the cause was not due to bacteria. General dosage: 200 to 400 mg for 7 to 14 days in 2 divided doses. Conclusion: Judicious selection and use of antibiotics is not only safe and effective but also can prevent development of microbial resistance. References: 1.Hamzeh et. al, American Journal of Infection Control 40 (2012), 776-7. 2. A Webber training telecast by Dr. Mark Thomas on antibiotic restriction policies, Fluroquinolone resistance. 3. Lisboa et. al, Amoxicillin dntal case study, American Journal of Infection Control 43 (2015), 766-8. 4. C.I.M.S 36th year, Jan to April 2015. NATIONAL PHARMACY WEEK 2016