From: Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Invest.

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Invest. Ophthalmol. Vis. Sci ;48(10): doi: /iovs Figure Legend:

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From: Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Invest. Ophthalmol. Vis. Sci.. 2017;58(1):660-669. doi:10.1167/iovs.16-20618 Figure Legend: Heatmaps assessing the effects of animal study methodologic parameters ([A] time-point, [B] tissue, [C] species, and [D] optical manipulation) on the pattern of overlapping results. The color of each heatmap square represents the odds ratio (larger odds ratios indicate a stronger association between lists), and the number of overlapping genes and significant Benjamini-Hochberg–adjusted P values (in parentheses where applicable) are superimposed on the grids. The total number of genes in each list is shown in parentheses after the list name. Note that all transcriptome studies sampled R/RPE/choroid, while proteomics studies were split into those sampling R/RPE/choroid and those sampling sclera. Prot, proteomics; R/RPE/choroid, retina, RPE and/or choroid tissue; Trans, transcriptome. Date of download: 10/24/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.