Biomolecular and Cellular Engineering Track Corey J. Bishop, Ph.D. Assistant Professor of Biomedical Engineering Principal Investigator of the Pharmacoengineering Laboratory Pharmacoengineering.com October 9, 2017

Scope of Courses Modern medicine and biotechnology deal with processes at the molecular and cellular levels. Focus: biological, physical, and quantitative foundations for understanding and manipulating biomolecules and cells

Courses Required: Others: 0-3 CH Track Courses: 6-9 CH BMEN 431 Biomolecular Engineering BMEN 433 Biomolecular and Cellular Engineering Laboratory Track Courses: 6-9 CH BMEN 2/491: Research with biomolecular and cellular engineering focus; BMEN 4xx Cellular Engineering; BMEN 471 Numerical methods for biomedical engineers (or BIOL 350 Computational genomics); BMEN 432 Molecular and cellular biomechanics; BMEN 486 Biomedical nanotechnology (OR BMEN 480 Biomedical Engineering of Tissues or BMEN 487 Drug Delivery) Others: 0-3 CH BMEN 4XX Elective; BMEN 404 FDA Good laboratory and clinical practices (or BMEN 406 Path to Market or BMEN 469 Entrepreneurial Issues in BME); CHEM 228 Orgo II; ENGR seminar I/II/III (181, 281, 381); ENGR 385 Co-Op; VTPP 401 History med. in Europe; VTPB Cell mechanics of disease

Courses Biomolecular Engineering Description: An introduction to concepts of bio-thermodynamics; provides a quantitative framework for describing materials behavior and processes, and their relation to properties and interactions of microscopic biological constituents. Also learn theoretical foundations for experimental approaches for measuring and manipulating biomolecules. Prerequisites or Co-requisites: Junior or Senior Classification in Biomedical Engineering, or approval of instructor. Basic knowledge of freshman-level physics and chemistry, and calculus (including partial derivatives and ordinary differential equations), are desired.

Courses Biomolecular and Cellular Engineering Laboratory

Courses 641. Numerical Methods in Biomedical Engineering (3-0). Credit 3. Application of numerical analysis to analyze molecular, cellular and physiological systems; general techniques used to analyze steady and dynamic systems; techniques will be applied in a MATLAB programming environment. Prerequisite: BMEN 207, BIOL 213 and VTPP 435.

Courses 432. Molecular and Cellular Biomechanics (3-0). Credit 3. II Introduces biomolecules and their assemblies that play structural and dynamical roles in sub-cellular to cellular level mechanics, with emphasis on quantitative/theoretical descriptions, and discussions of the relevant experiment approaches to probe these nano- to micro-scale phenomena; including topics in (1) self assembly of cytoskeleton and biomembranes, (2) molecular motors, (3) cell motility, and (4) mechanotransduction. Prerequisites: BMEN 361 and MATH 304.

Courses 486. Biomedical Nanotechnology (3-0). Credit 1. I Nanotechnology applications in biomedicine; concepts of scale; unique properties at the nanoscale; biological interaction, transport, and biocompatibility of nanomaterials; current research and development of nanotechnology for medical applications, including sensors, diagnostic tools, drug delivery systems, therapeutic devices, and interactions of cells and biomolecules with nanostructured surfaces. Prerequisite: BMEN 343; senior classification, or approval of instructor.

Courses 404. FDA Good Laboratory and Clinical Practices (3-0). Credit 3. Implementation of Good Laboratory Practices (GLP) for the submission of preclinical studies and use of Good Clinical Practices (GCP) in clinical trials in accordance with Food and Drug Administration (FDA) regulations; includes similarities and differences in GLP and GCP critical for the introduction of new drugs and medical devices.  Prerequisites: BMEN 430.

Courses 681. Seminar (1-0). Credit 1. Designed to permit student to broaden capability, performance and perspective in biomedical engineering via his or her own formal presentation and by presentations by other professionals. Prerequisite: Approval of instructor.