Date of download: 10/24/2017 Copyright © ASME. All rights reserved. From: On the Functional Role of Valve Interstitial Cell Stress Fibers: A Continuum Modeling Approach J Biomech Eng. 2017;139(2):021007-021007-13. doi:10.1115/1.4035557 Figure Legend: (Top) Schematic of the microindentation experimental configuration. (Bottom) the VIC model computational domains, which consisted of three subdomains, Ωcyto, Ωnuc, and Ωind, representing the cytoplasm, nucleus, and rigid spherical indenter, respectively. The cytoplasm was considered as a solid mixture of basal cytoplasm (green network in the inset) and oriented stress fibers (black oriented lines in the inset). The basal cytoplasm was modeled as a nearly incompressible neo-Hookean material. The stress fibers were modeled as the ensemble of oriented fibers with passive elastic and active contractile responses with their orientation described by a continuum orientation distribution function. The substrate was not explicitly modeled as the no-slip boundary condition was prescribed on Γbottom. The contact between the indenter and VIC was modeled by no-penetration, no-slip contact boundary condition.