Figure 1 C. LDH release D. Cell viability E. Cell proliferation (LDH assay, O.D.) D. Cell viability *** (MTT test, O.D.) E. Cell proliferation (BrdU incorporation, O.D.) B. Cell death area (mm2) A. Wound closure Hyperoxia (mm2 per 24 h) 0.1 0.2 0.3 0.4 0.5 0.25 0.75 1 1.25 0,05 0,1 0,15 Control in room air Figure 1

Figure 2 C. LDH release B. Cell death area A. Wound closure D. Cell viability E. Cell proliferation * 20 40 60 80 100 120 140 160 180 + 25 50 75 125 *** Control in room air Hyperoxia + KGF 10ng/ml + KGF 100ng/ml 150 200 250 300 350 400 500 600 700 800 900 1000 1100 +++ Figure 2

Survival rate Time (days) 0.2 0.4 0.6 0.8 1 2 4 6 8 10 Figure 3

Figure 4 Cells in BAL (x 10-4 / ml) ** 22.5 20 17.5 15 12.5 10 7.5 5 Control KGF Control KGF Room air Hyperoxia Figure 4

Figure 5 DNA content (µg / mg ww) *** 8 7 6 5 4 3 2 1 Room air 1 2 3 4 5 6 7 8 DNA content (µg / mg ww) Hyperoxia *** Figure 5

D C B A 100 µm Figure 6

Figure 7 Caspase-3 protein *** § day 5 day 10 room air hyperoxia day 5 day 10 Caspase-3 protein 20 40 60 80 100 120 % of day 5 room-air control 35kDa 19kDa 17kDa Ponceau S Figure 7