Characterization of Epstein-Barr virus–infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites Takenobu Yamamoto, MD,

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Presentation transcript:

Characterization of Epstein-Barr virus–infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites Takenobu Yamamoto, MD, Kazuyasu Fujii, MD, PhD, Kazuhide Tsuji, MD, PhD, Ayumi Akazai, MD, Megumi Oda, MD, PhD, Shosuke Imai, MD, PhD, Keiji Iwatsuki, MD, PhD Journal of the American Academy of Dermatology Volume 53, Issue 5, Pages 912-914 (November 2005) DOI: 10.1016/j.jaad.2005.05.002 Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Histopathologic findings of ulcerative forearm lesion: necrosis and infiltration of lymphoid cells in subcutaneous tissue. Infiltrates consist of many lymphoid cells and a few atypical cells. B, Immunostaining of ulcerative lesion for CD56. Journal of the American Academy of Dermatology 2005 53, 912-914DOI: (10.1016/j.jaad.2005.05.002) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Clonal analyses for EBV DNA containing terminal repeats. Single band showing clonal proliferation of EBV-infected cells is observed at 8.0 kb in lane 3 (cutaneous lesion [forearm]) and lane 4 (NOY-2 cell) and at 20 kb in lane 5 (NOY-1 cell). No clonal band is detected lane 6 (bone marrow) and in lane 7 (peripheral blood mononuclear cells). Lane 1, Positive control (B95.8); lane 2, negative control; M, size marker. Journal of the American Academy of Dermatology 2005 53, 912-914DOI: (10.1016/j.jaad.2005.05.002) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions