Personalized Medicine in Psychiatry

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Personalized Medicine in Psychiatry Acute antidepressant effects of deep brain stimulation – Review and data from slMFB- stimulation Bettina H. Bewernick, Sarah Kayser, Sabrina M. Gippert, Volker A. Coenen, Thomas E. Schlaepfer Personalized Medicine in Psychiatry Volume 3, Pages 1-7 (July 2017) DOI: 10.1016/j.pmip.2017.01.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 1 (draft). Time courses of antidepressant response in treatment-resistant depression. Note. Patients in DBS studies on treatment-resistant depression have many years in severe depression or several depressive episodes. Time courses of antidepressant response vary between different DBS targets. DBS to the slMFB was actually associated with the fastest response. Personalized Medicine in Psychiatry 2017 3, 1-7DOI: (10.1016/j.pmip.2017.01.002) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 2 Acute effect of intraoperative test. Note: Sum effect of DBS (sum effect left and right normalized to baseline) during intraoperative test stimulation as reported by the patients (DACS). Personalized Medicine in Psychiatry 2017 3, 1-7DOI: (10.1016/j.pmip.2017.01.002) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 3 Acute effects Patient #6. Note: Acute effects of DBS during surgery showing baseline, left and right stimulation for an individual patient for each item of the DACS (Depression acute-effects scale) Higher values reflect the negative dimension of each item. Personalized Medicine in Psychiatry 2017 3, 1-7DOI: (10.1016/j.pmip.2017.01.002) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 4 Acute effect of DBS per Item. Note: Sum of acute effect of left and right stimulation in individual patients, normalized to baseline score. Personalized Medicine in Psychiatry 2017 3, 1-7DOI: (10.1016/j.pmip.2017.01.002) Copyright © 2017 Elsevier Inc. Terms and Conditions