Carotid Artery Intima-Media Thickness and Subclinical Atherosclerosis in Women With Remote Histories of Preeclampsia: Results From a Rochester Epidemiology Project- Based Study and Meta-analysis  Vesna D. Garovic, MD, PhD, Natasa M. Milic, MD, PhD, Tracey L. Weissgerber, PhD, Michelle M. Mielke, PhD, Kent R. Bailey, PhD, Brian Lahr, MS, Muthuvel Jayachandran, PhD, Wendy M. White, MD, Howard N. Hodis, MD, Virginia M. Miller, PhD  Mayo Clinic Proceedings  Volume 92, Issue 9, Pages 1328-1340 (September 2017) DOI: 10.1016/j.mayocp.2017.05.030 Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Carotid artery intima-media thickness (CIMT) in women with histories of normotensive vs preeclamptic pregnancies. Line inside the box represents the median. The box represents interquartile range. Whiskers are extended to the most extreme data point that is no more than 1.5 × IQR from the edge of the box (Tukey style). All data points are presented individually by circles. Carotid artery intima-media thickness was greater in women with histories of preeclampsia than in those with histories of normotensive pregnancies (P=.004). Mayo Clinic Proceedings 2017 92, 1328-1340DOI: (10.1016/j.mayocp.2017.05.030) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Flowchart of the studies that were evaluated and included in the meta-analysis. CIMT = carotid artery intima-media thickness. Mayo Clinic Proceedings 2017 92, 1328-1340DOI: (10.1016/j.mayocp.2017.05.030) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Meta-analysis of differences in carotid artery intima-media thickness between women with vs without histories of preeclampsia. Studies are listed according to the average amount of time, in increasing order, from pregnancy to carotid artery intima-media thickness measurements. Std = standardized; IV = inverse variance. Orange boxes indicate standardized mean differences for individual studies, with size of the box corresponding to each study weight, and lines representing 95% confidence intervals; the blue diamond indicates overall effect size. Mayo Clinic Proceedings 2017 92, 1328-1340DOI: (10.1016/j.mayocp.2017.05.030) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions