Table 1 Characteristics of patients at enrollment who received artesunate-amodiaquine (ASAQ) or artemether-lumefantrine (AL) for treatment of malaria.

Slides:

Advertisements

Similar presentations

Malaria treatment (Current WHO recommendations & guidelines)

Advertisements

Malaria treatment. Dr abdulrahman al shaikh.. Introduction million patients died because of malaria every year. Most deaths due to Plasmodium Falciparum.

Drug-drug interaction Satellite Workshop

Choice of antimalarial drugs Malaria Medicines & Supplies Services RBM Partnership Secretariat.

history 1 ½ y boy Fever –2 weeks –Intermittent –39.5 –Chills and rigor –sweating.

Malaria pan-R Malaria cassette. Agenda Disease overview Infectious agents Diagnosis pan-R Malaria cassette: specifications Conclusion.

AMI -RAVREDA – USAID Project report, Colombia March 2009 Preliminary results on efficacy and Safety of Coartem ® on the treatment of Acute Uncomplicated.

Is antimalarial treatment in pregnant women as effective as that in non- pregnant women? Elizabeth Juma, Rashid Aman, Florence Oloo, Bernhards Ogutu Centre.

Homework 1 Part 2. Drug Resistance and Malaria Download “Drug Resistance and Malaria” by Peter Bloland, published by the World Health Organization:

Antimalarial Drugs.

Table 3 Clinical response success rate, according to prior effective antimicrobial therapy in hospitalized patients with community-acquired pneumonia given.

Figure 2 Power of likelihood ratio, log-rank, and Fisher’s exact tests as a function of the relative risk (RR) for different proportions of susceptible.

Table 4 Risk factors for acquisition of vancomycin-resistant enterococcal (VRE) colonization after transplantation for 120 liver transplant recipients.

Table 5 Characteristics of 12 patients who had 1 test of stool samples that yielded positive results in the prospective clinical assessment for investigation.

Table 3 Titers of antibody to hepatitis B surface antigen (anti-HBs) 2–4 weeks after the first vaccination From: Response to Hepatitis B Vaccine in HIV-1–Positive.

Table 1. Baseline Characteristics of the 36,636 Study Subjects

Table 6 The results of virus isolation tests before and after oseltamivir therapy. From: A Comparison of the Effectiveness of Oseltamivir for the Treatment.

Spread of a single multidrug resistant malaria parasite lineage (PfPailin) to Vietnam Mallika Imwong, Tran T Hien, Nguyen T Thuy-Nhien, Arjen M Dondorp,

Figure 1 Inclusion criteria, exclusion criteria, and criteria for virologic failure. CDC, Centers for Disease Control and Prevention; ddC, zalcitabine;

Malaria Prevention & Treatment in Pregnancy

Table 1 Groups of subjects in a study of the association between antibiotic use and colonization with resistant pneumococci. From: Measuring and Interpreting.

Figure 1 Principle coordinates analysis plot for 127 Escherichia coli isolates from the SENTRY and Meropenem Yearly Susceptibility Test Information Collection.

Table 3 Identification of Lactobacillus species isolated from blood cultures from Helsinki University Central Hospital, 1990–2000, and stored isolates.

Table 1 Demographic and clinical characteristics of 758 admitted patients for whom cultures of nares were performed to assess methicillin-resistant Staphylococcus.

Table 1 Specificity of IgM immunoblot assay of sera collected during the winter and early spring months from volunteers without clinical evidence of Lyme.

Table 1 Characteristics of study patients in survey of HIV infection in India. From: Natural History of Human Immunodeficiency Virus Disease in Southern.

Table 3. Predictors of Nevirapine Reactions at Antiretroviral Therapy Initiation From: Strategies for Nevirapine Initiation in HIV-Infected Children Taking.

Table 4 Comparison of frequencies of Legionella pneumophila serogroup 1 urinary antigen results and antibody titer results among patients with Pontiac.

Figure 1. Algorithm for classifying patients with hospital-acquired pneumonia according to the Consensus Statement of the American Thoracic Society. Adapted.

From: Unmasking Masks in Makkah: Preventing Influenza at Hajj

From: Rotarix: A Rotavirus Vaccine for the World

Figure 3. Estimated liver parasite load on day 6

Figure 4 Monthly all-cause (A-C) and pneumonia and influenza (P&I) mortality rates among Japanese children aged 5–9 years. Vertical dotted lines, January.

Table 1 Criteria for proven invasive fungal disease except for endemic mycoses. From: Revised Definitions of Invasive Fungal Disease from the European.

From: Postinfectious Irritable Bowel Syndrome

Figure 1 Adverse events after typhoid fever vaccination reported to the Vaccine Adverse Events Reporting System, by vaccination date and vaccine type,

Figure 2 In situ hybridization for rhinovirus type 14 (rhinovirus-14) in maxillary sinus biopsy specimens. A, Detection of rhinovirus-14, antisense probe,

Table 5 Sample format for results of Streptococcus pneumoniae isolate testing in a laboratory that routinely performs only oxacillin disk tests for penicillin.

Table 1 Baseline (before receipt of antiretroviral prophylaxis) characteristics of the pregnant women (transmitting or nontransmitting mothers included.

Figure 1 Annual per-capita consumption of all fermented milks and yogurt only in selected countries in Europe and North America [3, 4]. From: Probiotic.

Figure 1 Flow chart distinguishing groups according to receipt of azithromycin treatment and method of data collection. Circles containing the abbreviation.

Volume 369, Issue 9563, Pages (March 2007)

Comparison of current lowest global price vs estimated generic price, for medicines for diseases with large international treatment programmes. Comparison.

Emergence of Plasmodium falciparum triple mutant in Cambodia

M.L. McMorrow, M. Aidoo, S.P. Kachur

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

O. Clerc, G. Greub Clinical Microbiology and Infection

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax.

Malaria vaccines and the new malaria agenda

How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria

Spread of a single multidrug resistant malaria parasite lineage (PfPailin) to Vietnam Mallika Imwong, Tran T Hien, Nguyen T Thuy-Nhien, Arjen M Dondorp,

AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised,

Improved performance with saliva and urine as alternative DNA sources for malaria diagnosis by mitochondrial DNA-based PCR assays C. Putaporntip, P.

Volume 379, Issue 9830, Pages (May 2012)

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta- analysis Prof Ric N Price, MD, Lorenz von Seidlein, PhD, Neena.

Current strategies to avoid misdiagnosis of malaria

In vitro selection of antibiotic resistance in Pseudomonas aeruginosa

Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women F. Auquer, F. Cordón, E. Gorina, J.C. Caballero,

C. Wongsrichanalai, C.H. Sibley Clinical Microbiology and Infection

Figure 1. CONSORT flow diagram

Clinical Microbiology and Infection

O. Clerc, G. Greub Clinical Microbiology and Infection

Sanford Chodosh Clinical Microbiology and Infection

Novel Population-Level Malaria Treatment Strategies for the 2020s

Median parasite counts during the first 40 days of patent parasitemia for 69 patients infected with Plasmodium malariae. Median parasite counts during.

Q Fever: Epidemiology, Diagnosis, and Treatment

Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group† H. Goossens Clinical.

Proportions of patients with not serious, serious, or fatal disease with a diagnosis of P. falciparum or P. vivax infection and having parasitemias of.

Serum proteins dysregulated at baseline in patients enrolled in the MUSE study subsetted by IFNGS test status, Cutaneous Lupus Erythematosus Disease Area.

Gametocytes as an early indicator of parasite resistance.

Presentation transcript:

Table 1 Characteristics of patients at enrollment who received artesunate-amodiaquine (ASAQ) or artemether-lumefantrine (AL) for treatment of malaria. From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America

Figure 1 Flow of patients through the study Figure 1 Flow of patients through the study. AL, artemether-lumefantrine; ASAQ, artesunate-amodiaquine. From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America

Table 2 Falciparum malaria cure rates and likelihood-of-cure analyses associated with receipt of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL). From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America

Figure 2 Parasite clearance during the first 3 days of the follow-up period, revealed as the percentage of patients with parasitemia. AL, artemether-lumefantrine; ASAQ, artesunate-amodiaquine. Bars, 95% CIs. From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America

Figure 3 Fever clearance during the first 7 days of the follow-up period, revealed as the percentage of patients with a temperature of ⩾37.5°C. AL, artemether-lumefantrine; ASAQ, artesunate-amodiaquine. Bars, 95% CIs. From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America

Table 3 Proportions of Plasmodium falciparum harboring P Table 3 Proportions of Plasmodium falciparum harboring P. falciparum multidrug resistance gene 1 (pfmdr1) 86N at baseline and during breakthrough infection. From: Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania Clin Infect Dis. 2005;41(8):1079-1086. doi:10.1086/444460 Clin Infect Dis | © 2005 by the Infectious Diseases Society of America