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Supplemental Digital Content 2 Supplemental Digital Content 2 – Figure 2. Effects of sirolimus, tacrolimus and the combination of tacrolimus and sirolimus on glucose and insulin responses to oral glucose. The effects of four weeks of treatment with sirolimus (SIR), tacrolimus (TAC), tacrolimus plus sirolimus (TAC-SIR) or diluent (Control), administered as daily subcutaneous injections, are shown on the glucose response to an oral glucose load (Panel A), and the insulin response to an oral glucose load (Panel B). Means±SEM are shown. Insulin values in sirolimus-treated rats were higher than tacrolimus-treated rats (p < 0.05).