Esmolol is noninferior to metoprolol in achieving a target heart rate of 65 beats/min in patients referred to coronary CT angiography: A randomized controlled.

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Esmolol is noninferior to metoprolol in achieving a target heart rate of 65 beats/min in patients referred to coronary CT angiography: A randomized controlled clinical trial Pál Maurovich-Horvat, MD, PhD, MPH, FSCCT, Mihály Károlyi, MD, Tamás Horváth, MD, Bálint Szilveszter, MD, Andrea Bartykowszki, MD, Ádám L. Jermendy, MD, Alexisz Panajotu, MD, Csilla Celeng, MD, Ferenc I. Suhai, MD, Gyöngyi P. Major, MD, Csaba Csobay- Novák, MD, Kálmán Hüttl, MD, PhD, DSc, Béla Merkely, MD, PhD, DSc Journal of Cardiovascular Computed Tomography Volume 9, Issue 2, Pages 139-145 (March 2015) DOI: 10.1016/j.jcct.2015.02.001 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Flow chart of the study. bpm, Beats/min; CCTA, coronary CT angiography; HR, heart rate; IV, intravenous. Journal of Cardiovascular Computed Tomography 2015 9, 139-145DOI: (10.1016/j.jcct.2015.02.001) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 The figure represents the mean heart rates and their standard deviations in the esmolol and metoprolol groups at different time points. The red triangles represent the mean heart rates in the esmolol group, whereas the black squares indicate the mean heart rates in the metoprolol group. T1, time of arrival; T2, time point before the coronary CT angiography (CTA) scan; TS, coronary CTA scan; T3, time point immediately after the coronary CTA; T4, 30 minutes after the coronary CTA. *P < .01; ***P < .0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) Journal of Cardiovascular Computed Tomography 2015 9, 139-145DOI: (10.1016/j.jcct.2015.02.001) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 The bar charts illustrate the proportion of patients that reached a heart rate ≤60 beats/min (left side) and the proportion of patients that reached a heart rate ≤65 beats/min in the esmolol and metoprolol groups. Journal of Cardiovascular Computed Tomography 2015 9, 139-145DOI: (10.1016/j.jcct.2015.02.001) Copyright © 2015 The Authors Terms and Conditions