Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease Valérie.

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Presentation transcript:

Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease Valérie Zufferey, Alessia Donati, Julius Popp, Reto Meuli, Jérôme Rossier, Richard Frackowiak, Bogdan Draganski, Armin von Gunten, Ferath Kherif Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Volume 7, Pages 107-114 (January 2017) DOI: 10.1016/j.dadm.2017.05.002 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 (A) NEO Personality inventory (NEO-Pi-R) is hierarchical construct composed of 5 domains and 6 facets for each domain. (B) Search volume of interest with the hippocampus in yellow and parahippocampal cortex in red. (C) Multivariate Linear Model (MLM) identified the personality profile and the brain distributed pattern that best explain the covariance between personality scores and anatomical measures. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017 7, 107-114DOI: (10.1016/j.dadm.2017.05.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 MLM analysis of personality profile at domain level: (A) First Eigen-component (P <0.05) and (B) the associated spatial distribution within the search volume of interest for GMV; (C) First Eigen-component (P <0.05) and (D) the associated spatial distribution within the search volume of interest for GMMD. Abbreviations: Neuro, neuroticism; Extra, extraversion; Open, openness; Agree, agreeableness; Consc, conscientiousness. Y axis is an arbitrary unit (AU). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017 7, 107-114DOI: (10.1016/j.dadm.2017.05.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Hypothetical model of state marker in Alzheimer's disease (AD) including personality trait. The curves show the time evolution of state marker abnormality of AD. (A) Vulnerability: Individuals characterized with a different personality profile (e.g. with lower neuroticism score) can show different disease onset. (B) Pathoplasticity: Individuals characterized with a different personality profile (e.g. with lower neuroticism score) can show different rate of decline. X axis represents the time, and Y axis, the state biomarker abnormality of AD such as cognitive or brain decline. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017 7, 107-114DOI: (10.1016/j.dadm.2017.05.002) Copyright © 2017 The Authors Terms and Conditions