Neuropathology. Photomicrographs of the cerebellum

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Neuropathology. Photomicrographs of the cerebellum Neuropathology. Photomicrographs of the cerebellum. M—molecular layer; G—granular cell layer. A, Bielschovsky stain of normal cerebellum (10×) showing basket cell fibers surrounding Purkinje cells (arrow). B, Bielschovsky stain of cerebellum from an A-T patient (10×) showing empty basket cells (arrow) in the Purkinje cell layer. C, In situ hybridization with ATM cDNA on normal infant cerebellum (40×) showing a Purkinje cell (arrow) with a positive peroxidase stain for ATM mRNA. D, In situ hybridization with ATM cDNA on cerebellum from an A-T patient (20×) showing ectopic (overmigrated) Purkinje cells (arrow) with a positive peroxidase stain for ATM mRNA. (Courtesy of S. Becker-Catania.) Source: Ataxia-Telangiectasia, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: http://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch29fg2.png&sec=62665549&BookID=971&ChapterSecID=62665538&imagename= Accessed: October 25, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved