From: Upregulation of EphB2 and ephrin-B2 at the Optic Nerve Head of DBA/2J Glaucomatous Mice Coincides with Axon Loss Invest. Ophthalmol. Vis. Sci.. 2007;48(12):5567-5581.

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From: Upregulation of EphB2 and ephrin-B2 at the Optic Nerve Head of DBA/2J Glaucomatous Mice Coincides with Axon Loss Invest. Ophthalmol. Vis. Sci.. 2007;48(12):5567-5581. doi:10.1167/iovs.07-0442 Figure Legend: Spatial and temporal patterns of EphB2 and ephrin-B2 mRNA upregulation at the ONH. (A) Low-magnification view showing upregulated EphB2 mRNA expression at the ONH of an eye that showed clear optic disc cupping (arrow) in a 10-month-old DBA/2J mouse. Visualized by alkaline phosphatase histochemistry. (B) EphB2 mRNA upregulation was not detected at the ONH in an eye that showed no evidence of optic disc cupping in an 11-month-old DBA/2J mouse. (C) Low-magnification view showing upregulated ephrin-B2 mRNA expression at the ONH of an eye that showed clear optic disc cupping (arrow) in an 11-month-old DBA/2J mouse. (D) ephrin-B2 mRNA upregulation was not detected at the ONH in an eye that showed no evidence of optic disc cupping in an 11-month-old DBA/2J mouse. (E) PPD-stained tissue cross-section of the optic nerve from the eye in (A). Evidence of axon damage (dark profiles) can be seen. (F) PPD-stained tissue cross section of the optic nerve from the eye in (B) No evidence of axon damage is observed. (G) PPD-stained tissue cross section of the optic nerve from the eye in (C). Evidence of axon damage can be seen. (H) PPD-stained tissue cross section of the optic nerve from the eye in (D). No evidence of axon damage is observed. (All sections showing PPD staining, E–H, were obtained from the mid-central regions of the optic nerve.) (I) High-magnification view of EphB2 mRNA expression at the ONH of the same eye as in (A ) (10 months DBA/2J). The two arrows indicate the width of the ONH region. (J) High-magnification view of EphB2 mRNA expression at the ONH of the same unaffected eye shown in (B) (11 months DBA/2J). Arrows: examples of cells with faint EphB2 hybridization signal. (K) High-magnification view of ephrin-B2 mRNA expression at the ONH of the same eye as in (C) (11-month-old DBA/2J). Arrows: width of the ONH region. (L) High-magnification view of ephrin-B2 mRNA expression in the same unaffected eye as in (D) (11-month-old DBA/2J). Arrows: examples of cells with faint ephrin-B2 hybridization signal. (M) High-magnification view of EphB2 mRNA in situ hybridization pattern at the ONH of a 10-month-old C57Bl/6NCrl mouse. (N) EphB2 mRNA in situ hybridization pattern at the ONH of a 3-month-old DBA/2J mouse. (O) EphB2 mRNA in situ hybridization pattern at the ONH of an 8-month-old DBA/2J mouse. (P) In situ hybridization using an EphB2 sense control strand. (Q) High-magnification view of ephrin-B2 mRNA in situ hybridization pattern at the ONH of a 10-month-old C57Bl/6NCrl mouse. (R) ephrin-B2 mRNA in situ hybridization pattern at the ONH of a 3-month-old DBA/2J mouse. (S) ephrin-B2 mRNA in situ hybridization pattern at the ONH of an 8-month-old DBA/2J mouse. (T) In situ hybridization using an ephrin-B2 sense control strand. Scale bars: (A–D) 100 μm, (E–H) 20 μm; (I–T) 50 μm. Date of download: 10/25/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.