AIDS Chien-Ming Li MD, Ph.D.

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Presentation transcript:

AIDS Chien-Ming Li MD, Ph.D

Human Immuno-deficiency Virus (HIV) Is an RNA virus Causes AIDS: incurable Multiplies inside CD4+ cells Kills CD4 cells finally Risk factors: Man-to-man sex, heroin abuser

Life cycle of HIV Binding and Fusion Reverse Transcription Integration Assembly Budding

Stages of HIV infection Acute infection Flu-like symptoms Clinical latency Free of symptom Reproduces at very low level May last 10 years or so AIDS CD4+ cells < 200 per cubic milliliter Survives 3 years, without treatment

Anti-HIV drugs NRTI: nucleoside analogue reverse transcriptase inhibitor NNRTI: non-NRTI PI: protease inhibitor II: integrase inhibitor FI: fusion inhibitor CCR: chemokine coreceptor