Primary biliary cirrhosis

Slides:



Advertisements
Similar presentations
Two examples of incised wounds
Advertisements

Complex atypical hyperplasia of the endometrium
Salivary gland in a patient with Sjögren syndrome
Colonic adenocarcinoma metastases to the liver
The portal triad seen as three round anechoic structures within the liver (L). The largest posterior structure is the portal vein. The hepatic artery and.
The “mickey mouse” sign is made up of the three portal structures
The main pancreatic duct merges with the common bile duct at the hepatopancreatic ampulla, which enters the wall of the duodenum at a major papilla (of.
Abdominal aortic aneurysm (AAA or "triple A")
A. Schema of NSABP B-27 trial comparing neoadjuvant AC to neoadjuvant AC followed by neoadjuvant docetaxel and to neoadjuvant AC followed by adjuvant docetaxel.
Schema of the NSABP B-34 trial evaluating adjuvant oral clodronate in patients with resected stage I and II operable breast cancer (Chemo, adjuvant chemotherapy;
Large cell undifferentiated carcinoma of lung
Anatomy of the breast (diagrammatic sagittal section)
Calcific aortic stenosis
Desmoplastic small round cell tumor
Diagnostic approach: Dizziness.
(A) Multiple sigmoid diverticuli (white arrows) with linear tract containing air outside the bowel lumen consistent with a fistula (black arrow) as a complication.
Tenosynovial giant cell tumor Left low power view shows a lobulated tumor mass with lobules divided by thick collagen fibers (left, low-power view). High.
Normal gastric mucosa. (A) The epithelial component of the gastric mucosa consists of surface foveolar epithelium that is connected to the deep secretory.
PICC line thrombus (arrow) with 2D (A) and 3D (B) imaging.
Ductal carcinoma in situ (DCIS)
Angiosarcoma. (A) The dermis has been largely replaced by highly atypical cells in this patient with angiosarcoma. (B) Malignant cells form bizarre vascular.
A: Esophageal varices: Upper endoscopy demonstrates four columns of esophageal varices. A consequence of portal hypertension, esophageal varices are one.
Pathophysiology of alcoholic liver disease
Papillary serous carcinoma of the ovary
Abnormal intracellular accumulations: (A) Fatty change in liver (alcoholic steatosis): Tissue processed for H&E staining (lipid extracted). (Inset): Frozen.
The typical course of acute and chronic hepatitis C
Various developmental diverticulitis of the small bowel
(Figure 1–12c, with permission, from Dr Moise Bendayan, Departments of Pathology and Cell Biology, University of Montreal, Montreal, Canada.) Source: Chapter.
Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis 
Multiple transabdominal and transvaginal ultrasound images of a different patient with an ectopic pregnancy demonstrating (A) echogenic debris in the endometrial.
Chronic hepatitis C infection
Ulcerative colitis. Note the continuous segment of mucosal erythema extending from the distal aspect of the specimen (right of image). This pattern of.
Scaphoid fracture. A. Scaphoid fracture nonunion. B
Incidental significant finding on FDG-PET/CT
Nonalcoholic steatohepatitis (NASH)
Midsagittal section through the brain of a patient with a brain stem tumor. Histologic findings showed the tumor to be an ependymoma. Source: Discussion.
Large cell carcinoma. Note the marked pleomorphism, with no definitive squamoid or glandular differentiation apparent in this section. Most likely, large.
Patterns of ductal carcinoma in situ (DCIS)
Gallstones. Longitudinal ultrasonogram through the right upper quadrant. The gallbladder contains both sludge and stones (arrows). The gallstones are characteristically.
Fatty liver. In some cases, the fatty change seen in alcoholics will involve the entire liver (i.e., diffuse fatty liver). Fatty liver can also occur with.
Overview of eicosanoid synthesis: Some anti-inflammatory eicosanoids use parallel pathways substituting dihomo-gamma-linolenic acid (DGLA), a derivative.
Pancreatic lobule. Grossly and microscopically normal pancreatic tissue has a lobular architecture. The majority of the lobule is composed of acinar tissue.
Primary biliary cirrhosis developing in a patient with Crohn's disease during the course of infliximab treatment: The first case in the literature  Gurhan.
CMMl. PB smear (A, Wright stain, ×600)
Metastatic colon cancer
Focal nodular hyperplasia
(A) Region of esophagus demonstrating Barrett esophagus: The normal squamous epithelium (left margin of figure) is replaced by specialized columnar epithelium.
Structure of the intrahepatic biliary system
Columnar cell lesions and atypical ductal hyperplasia
Array technology permits simultaneous quantification of dozens to millions of analytes. In the array-based rtPCR panel depicted here, RNA is extracted.
Electrical burn on the foot of an individual who came into contact with a source of high voltage. There were corresponding burns on the sock and shoe,
Ischemic colitis. This example of ischemic colitis shows mucosal hemorrhage, necrosis of the superficial portions of the crypts, and lamina propria hyalinosis.
Gastrointestinal stromal tumor
A. Sites of the most severe pain during an episode of biliary pain in 107 patients with gallstones (% values add up to >100% because of multiple responses).
Anatomy of the colon. (A) Representation of the anterior portion of the colon. The right and left colic flexures are commonly referred to as the hepatic.
Iron deficiency anemia
Photomicrograph of bone biopsy with metastatic prostate adenocarcinoma
Follicular cysts. (A) Clinical presentation of follicular cysts
Transverse transabdominal sonography of two patients with complicated bladder diverticulum. (A) Sedimentation of infected urine (arrowheads) and thickening.
Positron emission tomography (PET scan)
The large hepatic portal vein that collects blood from various segments of the GI tract also perfuses the liver. Source: Drug Elimination and Hepatic Clearance,
Dilated bile ducts. A: CT shows a dilated distal bile duct (arrowhead)
Clinical and pathologic effects of hepatocellular failure, which commonly results from conditions associated with acute or chronic necrosis of liver cells.
Acute viral hepatitis. Acute viral hepatitis is most commonly characterized by lymphocyte predominant inflammatory infiltrates and foci of hepatocyte injury.
Primary biliary cirrhosis, cirrhotic stage
Chapter 12 Liver Transplantation 1
Primary biliary cirrhosis, AMA negative
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis 
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Presentation transcript:

Primary biliary cirrhosis Primary biliary cirrhosis. (A) In this biopsy of a patient with PBC, note the poorly formed granuloma (arrow) adjacent to a bile duct (arrowhead). (B) Elsewhere, there are increased numbers of lymphocytes (arrowheads) within bile duct epithelium. Source: Pathology of the Liver, Gallbladder, and Extrahepatic Biliary Tract, Pathology: A Modern Case Study Citation: Reisner HM. Pathology: A Modern Case Study; 2015 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/Books/1569/rei_ch10_f015.png&sec=95970114&BookID=1569&ChapterSecID=95970032&imagename= Accessed: October 25, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved