Effects of Medroxyprogesterone Acetate in Obstructive Sleep Apnea

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Effects of Medroxyprogesterone Acetate in Obstructive Sleep Apnea Krishnan R. Rajagopal, M.D., F.C.C.P., Peter H. Abbrecht, M.D., Ph.D., F.C.C.P., Bahman Jabbari, M.D. CHEST Volume 90, Issue 6, Pages 815-821 (December 1986) DOI: 10.1378/chest.90.6.815 Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 1 Percentage of total sleep time spent in episodes of apnea and disordered breathing before, during, and after treatment with medroxyprogesterone acetate (MPA). Values shown are means for all patients (±SE). There were no significant differences associated with treatment. CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 2 Mean duration of episodes of apnea and disordered breathing for all patients. Brackets indicate ± SE. There were no significant differences associated with treatment with medroxyprogesterone acetate (MPA). CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 3 Mean numbers of episodes of apnea of various durations for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. There were no significant differences associated with treatment. CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 4 Mean reduction in SaO2 occurring in episodes of apnea and disordered breathing for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. There were no significant differences associated with treatment. CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 5 Mean slopes of linear regressions of minute ventilation ( V ˙ E ) and occlusion pressure (P100) responses on expired Pco2 for all patients before, during and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. Asterisk indicates mean value obtained during treatment significantly greater (p<0.05) than before treatment. CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 6 Mean percentage of sleep time spent in different sleep stages for all patients before, during, and after treatment with medroxyprogesterone acetate (MPA). Brackets indicate ± SE. Asterisk indicates value after treatment significantly different (p<0.05) from during treatment and before treatment. CHEST 1986 90, 815-821DOI: (10.1378/chest.90.6.815) Copyright © 1986 The American College of Chest Physicians Terms and Conditions