Myoung J. Kang, Alistair Ingram, Hao Ly, Kerri Thai, James W. Scholey

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Presentation transcript:

Effects of diabetes and hypertension on glomerular transforming growth factor-β receptor expression Myoung J. Kang, Alistair Ingram, Hao Ly, Kerri Thai, James W. Scholey Kidney International Volume 58, Issue 4, Pages 1677-1685 (October 2000) DOI: 10.1046/j.1523-1755.2000.00328.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Western blot analysis and densitometry measures of transforming growth factor-βreceptor I (TGF-β RI) expression in spontaneously hypertensive rat (SHR) glomeruli after one week of hyperglycemia (A), after two weeks of hyperglycemia (B), and after insulin treatment to normalize blood glucose levels (C; N = 6, *P < 0.05). Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Western blot analysis and densitometry measures of TGF-β RII expression in SHR glomeruli after one week of hyperglycemia (A), after two weeks of hyperglycemia (B), and after one week of insulin treatment to normalize blood glucose levels (C; N = 6, *P < 0.05). Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Western blot analysis and densitometry measures of TGF-β RI expression (A) and TGF-β RII expression (B) in glomeruli from normal SHR (control) and uninephrectomized SHR (Unx, N = 6, *P < 0.05) after two weeks. Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Western blot analysis and densitometry measures of TGF-β RI expression (A) and TGF-β RII expression (B) in glomeruli from normal SHRs and normal WKY rats (N = 6). Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Western blot analysis and densitometry measures of TGF-β RI expression (A) and TGF-β RII expression (B) in glomeruli from control WKY rats and diabetic WKY rats (N = 6) after one week. Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 6 Western blot analysis and densitometry measures of TGF-β RI expression (A) and TGF-β RII expression (B) in glomeruli from control WKY rats and uninephrectomized WKY rats (N = 6) after one week. Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 7 Western blot analysis and densitometry measures of TGF-β RI expression (A) and TGF-β RII expression (B) in glomeruli from control WKY rats and uninephrectomized diabetic WKY rats (N = 4) after one week. Kidney International 2000 58, 1677-1685DOI: (10.1046/j.1523-1755.2000.00328.x) Copyright © 2000 International Society of Nephrology Terms and Conditions