Delphine Ribes (Internship UNC 2005/2006) Guido Gerig

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Presentation transcript:

Delphine Ribes (Internship UNC 2005/2006) Guido Gerig Cortical Thickness Analysis Delphine Ribes (Internship UNC 2005/2006) Guido Gerig

Grey Matter exterior boundary Project Measure Cortical Thickness by using the Danielsson Distance Transform ? White matter Boundary Grey Matter exterior boundary ? Cortical Thickness ?

Just another cortical thickness method … Given imperfect, somewhat noisy tissue images Perfect, topologically correct surface cannot be obtained Not necessary to inflate cortex Display on wm and gm surfaces Separate measure of thickness inside folds and on outer cortex Choice: “Engineering method” based on Euclidean distance transform Good enough to collect statistics across cortical areas, not precise measurements at each voxel

Danielsson Distance Map Cortical Thickness Pipeline : Danielsson Distance Map Brain Seg Image Vector Map Distance Maps White and Grey

Grey Matter exterior boundary Distance Maps White and Grey Grey Matter exterior boundary White matter Boundary Vector Map Problem : Each grey matter voxel points to white matter surface Gray matter surface in folds is not known Solution : At each wm surface point, choose the grey matter voxel distance with maximum distance Method : Maximum Operator => For each white Matter point, find the furthest grey Matter point

Summary: Procedure Distance gray matter surface to white matter boundary Tissue Segmentation Cortical thickness for full brain and for individual lobes Lobe Parcellation

Status Tool fully written in ITK Toolkit available on UNC website and compiled on UNC dashboard Visualization with NA-MIC MeshVisu (Oguz) Comprehensive manual, very easy to use Might go very well with EMS (needs tissue segmentation and parcellation)