Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance.

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Presentation transcript:

Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry Jana Tomková, Peter Ondra, Ivo Válka Forensic Science International Volume 251, Pages 209-213 (June 2015) DOI: 10.1016/j.forsciint.2015.04.007 Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Chemical structures of α-amanitin (R=NH2) and β-amanitin (R=OH). Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Chemical structures of internal standard phallacidin. Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Chemical structures of muscarine. Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Extracted ion chromatograms of human urine spiked with α-amanitin (10ng/mL), β-amanitin (10ng/mL), muscarine (1ng/mL), and phallacidin (IS, 100ng/mL) obtained by UHPLC-UHR-TOF MS. Extracted ions: for α-amanitin 919.3614, for β-amanitin 920.3454, for muscarine 174.1489 and for phallacidin 847.3291. Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Magnified profiles of the protonated molecular ions or the charged molecular ion and their isotope peaks obtained by ultra-high-resolution TOF MS: α-amanitin: the protonated molecular ion (A), β-amanitin: the protonated molecular ion (B), muscarine: the charged molecular ion (C) and internal standard phallacidin: the protonated molecular ion (D). Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 UHPLC-UHR-TOF MS analysis of boy's urine (——, full line) and negative human urine (- - -, dashed line). Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 7 UHPLC-UHR-TOF MS analysis of female's urine (——, full line) and negative human urine (- - -, dashed line). Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Forensic Science International 2015 251, 209-213DOI: (10. 1016/j Forensic Science International 2015 251, 209-213DOI: (10.1016/j.forsciint.2015.04.007) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions