Figure 1. Structural formulae of buprenorphine, norbuprenorphine and their deuterated analogs (*, site of glucuronidation). From: Buprenorphine Detection.

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Figure 1. Structural formulae of buprenorphine, norbuprenorphine and their deuterated analogs (*, site of glucuronidation). From: Buprenorphine Detection in Urine Using Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Cloned Enzyme Donor Immunoassay (ThermoFisher) and Homogeneous Enzyme Immunoassay (Immunalysis) J Anal Toxicol. 2014;38(7):438-443. doi:10.1093/jat/bku060 J Anal Toxicol | © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Table I LC–HR-MS Assay: Summary Accuracy and Precision Data From: Buprenorphine Detection in Urine Using Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Cloned Enzyme Donor Immunoassay (ThermoFisher) and Homogeneous Enzyme Immunoassay (Immunalysis) J Anal Toxicol. 2014;38(7):438-443. doi:10.1093/jat/bku060 J Anal Toxicol | © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Figure 3. Percentage of buprenorphine and metabolites (nmol/L) detected in patient urine samples (N = 75). From: Buprenorphine Detection in Urine Using Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Cloned Enzyme Donor Immunoassay (ThermoFisher) and Homogeneous Enzyme Immunoassay (Immunalysis) J Anal Toxicol. 2014;38(7):438-443. doi:10.1093/jat/bku060 J Anal Toxicol | © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com