Leukocytes (WBCs) Crucial in the body’s defense against disease These are only complete cells in blood Diapedesis:

Leukocytes (WBCs) Positive Chemotaxis Can move by amoeboid motion 4,000 to 11,000 WBC per cubic millimeter of blood

Abnormal numbers of leukocytes Leukocytosis WBC count above 11,000 leukocytes/mm3 Generally indicates an infection Leukopenia Abnormally low leukocyte level Commonly caused by certain drugs such as corticosteroids and anticancer agents Leukemia Bone marrow becomes cancerous, turns out excess WBC

Types of leukocytes Granulocytes Include neutrophils, eosinophils, and basophils

Types of Granulocytes Agranulocytes Include lymphocytes and monocytes

Formed Elements List of the WBCs from most to least abundant Neutrophils Lymphocytes Monocytes Eosinophils Basophils

Types of granulocytes Neutrophils Multilobed nucleus with fine granules

Types of granulocytes Eosinophils Large brick-red cytoplasmic granules

Types of granulocytes Basophils

Types of agranulocytes Lymphocytes

Types of agranulocytes Monocytes

Formed Elements Platelets Derived from ruptured multinucleate cells (megakaryocytes) Normal platelet count = 300,000/mm3

Formed Elements Hemocytoblast stem cells Secondary stem cells Basophils Eosinophils Neutrophils Monocytes Lymphocytes Erythrocytes Platelets Lymphoid stem cells Myeloid stem cells Figure 10.4