The DMDG In-Vitro Technology Training Course Day 1 12.00 - 14.00 Delegate Arrival and Registration 14.00 - 14.15 Course Introduction 14.15 - 15.00 Drug Metabolism and Phase I 15:00 - 15.30 Phase II Enzymes 15:30 - 16.00 Coffee 16.00 - 16.30 Introduction to Transporters 16.30 - 17.30 Tutorial 1 (Routes of ADME) 18.30 – 20:00 Dinner 20:00 – 23:00 Quiz Day 2 09.00 - 09.45 Hepatocytes 09:45 - 10.15 Sub cellular fractions 10.15 - 10.45 Coffee 10.45 - 11.30 Enzyme Kinetics & Clearance 11.30 - 13.00 Tutorial 2 (Enzyme Kinetics) 13.00 - 14.00 Lunch 14.00 - 14.45 Molecular Methods 14.45- 15.15 Transporter Phenotyping 15.15 - 15.45 Coffee 15:45 – 17:30 Tutorial 3 (Clearance & Transporters) 19.00 Dinner + Free evening Day 3 09.00 - 09.45 Inhibition of ADME 09:45 - 10.30 Induction of ADME 10:30 - 11.00 Coffee 11.00 - 12.30 Tutorial 4 (ADME Inhibition & Induction) 12:30 - 13.30 Lunch 13.30 - 14.00 In Vitro – In Vivo extrapolation 14.00 - 14.45 Applications of In Vitro 15.00 - 15.30 Coffee 15.30 - 15.45 Tutorial 5 intro 15.45 – 17.45 Tutorial 5 17.45 – 18.00 Tutorial 5 – Discussion/presentation 20.00 Course Dinner Day 4 09.00 Delegates Depart *In the event of oversubscription, places will be allocated according to DMDG rules.