Ag and Au nanoparticles (NPs) UFN Ag and Au nanoparticles (NPs)

Nanomaterials 2 one dimension < 100 nm (1 m) Amin, M. T. et al. Adv. Mater. Sci. Eng. 2014, 825910.

Nanomaterials 3 https://ninithi.files.wordpress.com/2015/07/nanomataterials.jpg

Au and Ag NPs 4 100 nm Au nanoparticles Au nanoshapes Ag nanocarrot Ag nanorice Au nanocages Au nanoframes Liang, H.-Y. et al. Front. Phys. 2016, 11, 117301. Sajanlal P. R. et al. Nano Rev. 2011, 2, 5883.

Nanoparticles (NPs) 5 Sajanlal P. R. et al. Nano Rev. 2011, 2, 5883.

Příprava nanočástic 6

Příprava nanočástic 7 Supercritical Atomization Jet-milling

Význam povrchových atomů 8 Repeat 24 times For example, 5 cubic centimeters – about 1.7 cm per side – of material divided 24 times will produce 1 nanometer cubes and spread in a single layer could cover a football field. Source: Clayton Teague, NNI

Význam povrchových atomů 9 podíl atomů na povrchu < 3,5 nm > 10 nm

Analýza nanočástic 10 SEM TEM AFM DLS

AuNPs – history 11 4th – 5th century B.C. Middle Ages – for the diagnosis of syphilis (the test is not reliable) 1718 – use of boiled starch in drinkable gold preparation noticeably enhanced its stability 1857 – Michael Faraday reported the formation of deepred solutions of colloidal gold by reduction of an aqueous solution of chloroaurate (AuCl4-) using phosphorus in CS2 (a two-phase system). Daniel, M.-C. et al. Chem. Rev. 2004, 104, 293–346. http://2.bp.blogspot.com/-L7gtEPCyZ5U/Ui0X0PBItiI/AAAAAAAAHIg/UDAYOEOSLgE/s1600/lycurgus+cup.jpg

AuNPs preparation 12 Turkevitch in 1951 Brust-Schiffrin in 1994 Daniel, M.-C. et al. Chem. Rev. 2004, 104, 293–346. http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ ImageService/Articleimage/2013/CC/c2cc35720h/c2cc35720h-f1.gif

AuNPs applications 13 Human chorionic gonadotropin (hCG) Immunoglobulin G (IgG) antibody-antigen interactions Yeh, C.-H. et al. Sensors 2014, 14, 16148–16158.

AgNPs applications 14 https://www.nanosilver.cz/

AuNPs 15 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Capping agents 16 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Capping agents 17 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP, -SH ligands 18 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP, -SH ligands 19 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Coupling of peptides 20 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Bioconjugation of AuNPs 21 arginine–glycine–aspartic acid (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Bioconjugation of AuNPs 22 Kim, Y.-H. et al. Small 2011, 7, 2052–2060.

Bioconjugation of AuNPs 23 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Doxorubicin conjugates 24 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Doxorubicin conjugates 25 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Doxorubicin conjugates 26 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP and CuAAC 27 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Modification of Au nanorods 28 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Luciferase-AuNP 29 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Noncovalent conjugation 30 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

Noncovalent conjugation 31 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP-oligonucleotide 32 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP-oligonucleotide 33 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP-transferrin 34 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.

AuNP-transferrin 35 (1) Sapsford, K.-E. et al. Chem. Rev. 2013, 113, 1904–2074.