Prepared By: Heba Mohamed Fahmy, PhD

Slides:

Advertisements

Similar presentations

Introduction to Pathology By Dr. Gehan Mohamed Dr. Abdelaty Shawky.

Advertisements

IIUM Research, Invention and Innovation Exhibition 2011 Enhancing Quality Research and Innovation for Societal Development Norsidah Ku zaifah a, Ahmad.

The MS Clinic Alastair Lansbury Neurologist. What is MS ? Inflammatory Central Nervous System Autoimmune Relapses and remission (Progressive forms) Any.

Amelioration of Hyperalgesia by Gliclazide and Some Antioxidants in STZ diabetic Animals Hekma A. Abd El-Latif * Hekma A. Abd El-Latif * Abstract Neuropathy.

MHC II α1α1 α2α2 β1β1 β2β2 membrane Peptide-binding cleft There are two alleles associated with MS DR15 DQ6 There are two protective alleles HLA-C554.

 Evaluation of interaction between Vitamin D 3 and neural stem cell proliferation and differentiation in to oligodendrocyte as the myelinating cell 

TRANSLATIONAL RESEARCH New Therapies for MS Dennis Bourdette, M.D. and Arthur A. Vandenbark, Ph.D. TCR peptide therapy Recombinant TCR ligand (RTL) therapy.

Doug Brutlag 2011 Genomics, Bioinformatics & Medicine Doug Brutlag Professor Emeritus of.

Worm therapy: Multiple Sclerosis

“Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis” Lee YK, Menezes JS, Umesaki Y, & Mazmanian SK PNAS.

Anti-inflammatory effect of meloxicam on experimental vasospasm in rat femoral artery Tayfun Hakan, M. Zafer Berkman, Turgay Ersoy, Ismail Karatas, Tangul.

The authors have no financial interest in the subject matter of this poster. The Effect of Topical Epigallocatechin Gallate (EGCG) Treatment on Murine.

Research Number (10). Comparative Evaluation on the Effect of Coccidiostate and Synbiotic Preparations on Prevention of Clostridium perfringens in Broiler.

Polyherbal Formulations for Diabetes Prof. Dr. Basavaraj K. Nanjwade. M.Pharm., Ph.D. Department of Pharmaceutics KLE University College of Pharmacy Belgaum,

Crocins, the active constituents of Crocus Sativus L., antagonized psychotomimetic effects produced by the NMDA receptor antagonist ketamine in rats G.

Dr. Mariam Eshak 2015 Expression of Inflammatory and Cell Death Genes and DNA Damage Induced by Endotoxic Shock in Laying Hens Mariam G. Eshak 1, Ahmed.

Statin Use Reduces Decline in Lung Function. Introduction  Lung function has been shown to predict both cardiovascular mortality and total mortality.

Research Number (9). Certain Epidemiological Aspects of Aeromonas hydrophila Infection in Chickens M. H. H. Awaad 1, M. E. Hatem 2, Wafaa A. Abd El-Ghany.

Aim - to investigate the biological activity of materials based on gold (Au-VO) and silver (Ag-VO) nanoparticles and natural compounds extracted from European.

Oxidative Stress, Septic Shock, and Survival Matthew Greenwood April 29, 2015.

A Randomized Placebo-Controlled Phase III Trial of Oral Laquinimod for Multiple Sclerosis Timothy L. Vollmer, MD Professor, Neurology and Neuroscience.

The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats Hala O El Mesallamy, Nadia S Metwally2, Mahmoud.

Peptides from Scorpion Venom and Autoimmune diseases K. George Chandy, Department of Physiology and Biophysics, University of California Irvine.

M. A. Tony 1, Wafaa A. Abd El-Ghany 2 and Samah H. Mohamed 3 1 Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Cairo University.

Daily used nanoparticles increases the incidence of cancer presented by Hanan Ramadan Hamad Mohamed Zoology Department Faculty of Science Cairo University.

This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition.

Dennis Bourdette, MD VA MS Center of Excellence-West and

Research Number (8). The in-vitro and in-vivo Evaluation of Tiamulin and Tilmicosin for the Treatment of Mycoplasma gallisepticum Infected Broiler Chickens.

Neurobehavioural, neurochemical and neuromorphological effects of cadmium in male rats By Hussein A.Kaoud, Mervat M.Kamel, Abeer H. Abdel-Razek, Gehan.

Cancer Research in Egypt: A Focus on Tanta University Prepared by Shymaa Sobhy, Faculty of Science Mona Zidan, Faculty of Science Mohamed Basiony, Faculty.

Research Number (1). The effect of a combination of β(1-3) D- Glucan and Propionibacterium granulosum on productive performance and immune modulation.

Maria Rosana Ramirez, PhD, Prof.

Antiinflamatory effect of materials based on gold and silver nanoparticles and Sambucus Nigra L. on carrageenan- induced rat paw edema Adriana Filip a,

PATHOLOGICAL STUDIES ON INDUCED HEPATIC CIRRHOSIS WITH EVALUATION OF SOME HEPATOPROTECTIVE MATERIALS IN RATS PhD 2016.

Using the Case Study To Develop Student Researcher-Thinker- Communication Skills Sheryl Gares, Ph.D. Augustana Campus, University of Alberta.

Hepatic Steatosis in patients with Autoimmune Hepatitis (AIH) – prevalence, progression and possible significance C. Salmon*1, B.Hoeroldt2, A. Dube3,

Sindhu G. & Dr. A. Helen Department of Biochemistry

International Neurourology Journal 2014;18:

Curcumin could ameliorate diabetic vascular inflammation

Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis Dariush Haghmorad, Mohammad Bagher.

SEMINAR 1. Title : Direct measurements of inter-membrane forces using Surface Forces Apparatus (SFA): Role of membrane protein concentrations and lipid.

3Departement of Biochemistry, Hospital La Rabta Tunis. Tunisia.

International Neurourology Journal 2016;20:26-32

Polyherbal Formulations for Diabetes

Morozova A.Y., Zubkov E.A., Chekhonin V.P.

Faezeh Tashakori Sabzevar

Pilot clinical trial of curcumin for treating Alzheimer's disease

COMPARATIVE TOXICITY STUDY OF CHLOROQUINE AND HYDROXYCHLOROQUINE ON ADULT ALBINO RATS M.A. El Shishtawy,K. Haidar Hassan .Department of Forensic Medicine.

Elham Ghanbari, Mozafar Khazaei

ACUTE TOCOMIN TREATMENT RESTORES ENDOTHELIUM-DEPENDENT RELAXATION IN AORTAE FROM DIABETIC AND WESTERN DIET FED RATS SF Ali, JCD Nguyen, TA Jenkins & OL.

Protective effect of Piper betle leaf extract against cadmium-induced oxidative stress and hepatic dysfunction in rats King Saud University Saudi Journal.

(vi) AMI+Rotenone H&E X 20

Mohamed Elbandy1, 2 and Ihab Ashoush3

Introduction to Pathology DR:Gehan mohamed

Hypoglycaemic potential of Tapinanthus bangwensis

Periulcerous inflammation

دانشگاه شهیدرجایی تهران

Methods Objectives Results Conclusions References

تعهدات مشتری در کنوانسیون بیع بین المللی

Mehdi Kian1, Ali Soleimanzadeh1*, Shahram Javadi2, Gholamreza Najafi3

How Attenuation Of Microglial Cell Using Cre-Lox Can Effect Pathology of EAE Induce Mice By Kevin Limlengco.

Volume 19, Issue 9, Pages (September 2012)

Effects of lipoic acid supplementation on activities of cyclooxygenases and levels of prostaglandins E2 and F2 metabolites, in the offspring of rats with.

Figure S4 A C Vehicle control AC0010 (300mg/kg) Gefitinib (50mg/kg) D

Figure 6 Laquinimod treatment of spontaneous EAE prevents progression and reduces the frequency of Tfh cells Laquinimod treatment of spontaneous EAE prevents.

Volume 18, Issue 4, Pages (April 2010)

Figure 4 Laquinimod treatment suppresses development of spontaneous EAE Laquinimod treatment suppresses development of spontaneous EAE (A) 2D2 × Th mice.

CBD Oil for Chronic Pain Researchers in the same report also note that there is substantial evidence that CBD oil is an.

Table 1. Histological disease score

Presentation transcript:

Prepared By: Heba Mohamed Fahmy, PhD Nigella sativa as an anti-inflammatory and promising remyelinating agent in the cortex and hippocampus of experimental autoimmune encephalomyelitis-induced rats Prepared By: Heba Mohamed Fahmy, PhD Lecturer at Biophysics Department, Faculty of Science, Cairo University, Egypt

Introduction and aim of the study What is multiple sclerosis (MS)? What is experimental autoimmune encephalomyelitis (EAE)? What is Nigella sativa (N. sativa)? The aim of the present study was to investigate the protective and therapeutic effects of the whole N. sativa seeds (2.8 gm / kg of animal weight) in the EAE-induced rats.

Animals were randomly divided into 4 groups Materials and Methods Animals were randomly divided into 4 groups “Control” group “EAE” group “EAE + N. sativa” group “N. sativa + EAE” group Open field test Daily clinical scoring Body weight Disease monitoring Histopathological examination Ultrastructural examination Oxidative stress parameters

Nigella sativa suppresses inflammation in the EAE-induced groups Results Daily clinical scoring Body weight Open field test Histopathological examination Nigella sativa suppresses inflammation in the EAE-induced groups

Ultrastructural examination Cortex Hippocampus

Oxidative stress parameters Cortex

Hippocampus

Conclusions The whole N. sativa seeds attenuate the clinical signs, suppress inflammation and lead to marked remyelination in EAE-induced Wistar rat. N. sativa seeds could provide a promising agent effective in both the protection and treatment of EAE even when the treatment started after the appearance of first clinical signs.

Thank you for your attention Any questions?