The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis Pharmacology 2013;92:14-25 - DOI:10.1159/000351843 Fig. 1. Relationship between potential sites of action and volume of distribution of common H1 antagonists (adapted from Tillement [22]). Volume of distribution values cited from Gillman et al. [91] and Chu et al. [92]. © 2013 S. Karger AG, Basel

The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis Pharmacology 2013;92:14-25 - DOI:10.1159/000351843 Fig. 2. Binding affinity of histamine antagonists for human histamine H1 receptors (adapted from Gillard et al. [28]). Ki = Inhibition constant, the lower the amount of a drug needed to inhibit the H1 receptor, the higher its affinity. © 2013 S. Karger AG, Basel

The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis Pharmacology 2013;92:14-25 - DOI:10.1159/000351843 Fig. 3. Inhibition of the skin wheal formation in healthy volunteers following the intradermal injection of histamine, and after prior oral administration of different antihistamines (adapted from Grant et al. [37]). The inhibition of the flare formation was similar (not shown). © 2013 S. Karger AG, Basel