From: Deficiency of SHP-1 Protein-Tyrosine Phosphatase in “Viable Motheaten” Mice Results in Retinal Degeneration Invest. Ophthalmol. Vis. Sci.. 2006;47(3):1201-1209. doi:10.1167/iovs.05-1161 Figure Legend: Temporal progression of retinal degeneration in B6-me v /me v mice. Representative photomicrographs of retinal sections (A) and ERGs (B, C) from a littermate control mouse at 3 months of age and from B6-me v /me v mice at 1, 2, and 3 months of age. me v /me v mice had a progressive loss of photoreceptors and outer segments, as evidenced by a reduction in the thickness and density of the ONL and outer segments (A). GC, ganglion cell layer; INL, inner nuclear layer; IS, OS, inner and outer segments, respectively; PE, pigment epithelium. Scale bar, 100 μm. The dark-adapted rod ERGs in me v /me v mice were similar in waveform to those in control mice; however, the amplitude of both the a- and b-waves were progressively attenuated with age (B). The a- and b-wave amplitudes were increased over control mice in the cone ERGs of the 1- and 2-month-old me v /me v mice. By 3 months of age, the wave amplitudes of cone ERGs in me v /me v mice were decreased compared with age-matched control mice (C). Date of download: 10/26/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.