(A) A young adult Snell dwarf mouse, with a littermate control (on the vehicle). (B) Survival curves for Snell dwarf (dw/dw) mice and littermate controls.

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Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

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(A) A young adult Snell dwarf mouse, with a littermate control (on the vehicle). (B) Survival curves for Snell dwarf (dw/dw) mice and littermate controls. (C) Glomerular basement pathology scores, at terminal necropsy, for Snell dwarf (N = 40) and control (N = 46) mice. Higher scores indicate a greater degree of kidney pathology. Despite living 40% longer, a higher percent of Snell dwarfs had 0 scores at necropsy and a smaller percent had scores of 2 or 3. (D) Cataract scores determined by slit lamp examination in Snell dwarf and littermate control mice at 18 and 24 months of age. p < 0.001 for the difference between dwarfs and controls at each age. (B) Data from Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A. 2001;98(12):6736–6741. (C and D) Data from Vergara M, Smith-Wheelock M, Harper JM, Sigler R, Miller RA. Hormone-treated Snell dwarf mice regain fertility but remain long-lived and disease resistant. J Gerontol Biol Sci. 2004;59:1244–1250. Source: Chapter 1. Biology of Aging and Longevity, Hazzard's Geriatric Medicine and Gerontology, 6e Citation: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S. Hazzard's Geriatric Medicine and Gerontology, 6e; 2009 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/halt6/halt6_c001f001c.gif&sec=41587778&BookID=371&ChapterSecID=41587604&imagename= Accessed: October 26, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved