Facilitating pharmacometric workflow with the metrumrg package for R

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Presentation transcript:

Facilitating pharmacometric workflow with the metrumrg package for R Timothy T. Bergsma, William Knebel, Jeannine Fisher, William R. Gillespie, Matthew M. Riggs, Leonid Gibiansky, Marc R. Gastonguay  Computer Methods and Programs in Biomedicine  Volume 109, Issue 1, Pages 77-85 (January 2013) DOI: 10.1016/j.cmpb.2012.08.009 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Kinetics: visualization of concentration–time profiles with dosing history. Units are arbitary for this example; see text. (For interpretation of the references to color in the text, the reader is referred to the web version of the article.) Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Covariate effects on clearance: visualization of bootstrap parameter estimates. CL: typical clearance. Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Diagnostics: observed concentrations vs. model-based individual and population predictions. Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Median overlay: using actual times (left) vs. “snapped” times (right). Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10.1016/j.cmpb.2012.08.009) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

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