Free energy folding landscape for a hypothetical protein

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Free energy folding landscape for a hypothetical protein Free energy folding landscape for a hypothetical protein. The free energy (vertical axis) is plotted against a two-dimensional representation of the conformational space. The lines represent two examples for routes of individual molecules upon their folding. Arrows point to local minima where semistable conformations may become kinetically trapped. Source: Protein Folding and Misfolding: The Role of Cellular Protein Quality Control Systems in Inherited Disorders, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch13_1fg4.png&sec=62640508&BookID=971&ChapterSecID=62640472&imagename= Accessed: October 26, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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