Antithrombin Administration in Patients With Low Antithrombin Values After Cardiac Surgery: A Randomized Controlled Trial Domenico Paparella, MD, Crescenzia.

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Presentation transcript:

Antithrombin Administration in Patients With Low Antithrombin Values After Cardiac Surgery: A Randomized Controlled Trial Domenico Paparella, MD, Crescenzia Rotunno, BS, Micaela De Palo, MD, Simona Finamore, MD, Pietro Guida, PhD, Gianni Rubino, MD, Luigi de Luca Tupputi Schinosa, MD, Tommaso Fiore, MD The Annals of Thoracic Surgery Volume 97, Issue 4, Pages 1207-1213 (April 2014) DOI: 10.1016/j.athoracsur.2013.11.040 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Antithrombin (AT) levels in control patients (Controls; black bars), patients receiving AT (white bars), and those receiving placebo (no AT; gray bars), measured preoperatively (Pre-op), on intensive care unit acceptance (ICU), 90 minutes after the first AT administration (90′ AT), 1 hour after the last AT administration (1h AT), 24 hours after the last AT administration (24h AT), 48 hours after the last AT administration (48h AT), and on the fifth postoperative day (day 5). Values are reported as mean ± standard error. The Annals of Thoracic Surgery 2014 97, 1207-1213DOI: (10.1016/j.athoracsur.2013.11.040) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Prothrombin fragment 1.2 (PF-1.2), (B) plasmin–antiplasmin complex (PAP), (C) interleukin 6 (IL-6), (D) and platelet factor 4 (PF4) in control patients (Controls; triangles and dashed lines), patients receiving antithrombin (AT; circles and solid lines), and those receiving placebo (no AT; squares and solid lines), measured preoperatively (Pre-op), on intensive care unit acceptance (ICU), 90 minutes after the first AT administration (90′ AT), 1 hour after the last AT administration (1h AT), 24 hours after the last AT administration (24h AT), 48 hours after the last AT administration (48h AT), and on the fifth postoperative day (day 5). Values are reported as mean ± standard error. The Annals of Thoracic Surgery 2014 97, 1207-1213DOI: (10.1016/j.athoracsur.2013.11.040) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions