Copyright © 2015 by the American Osteopathic Association. From: Insulin Analog Therapy: Improving the Match With Physiologic Insulin Secretion J Am Osteopath Assoc. 2009;109(1):26-36. doi:10.7556/jaoa.2009.109.1.26 Figure Legend: Comparison of human (A) and analog (B) basal-bolus insulin regimens. The shaded areas depict normal insulin secretion, thus showing the relationship of each insulin therapy to normal physiologic conditions. Abbreviations: B, breakfast; HS, bedtime; L, lunch; NPH, neutral protamine Hagedorn; S, supper. Source: Edelman SV, Morello CM. Strategies for insulin therapy in type 2 diabetes. South Med J. 2005;98:363-371.25 Copyright Southern Medical Association. Modified with permission of Lippincott Williams & Wilkins. Date of download: 10/26/2017 Copyright © 2015 by the American Osteopathic Association. All rights reserved.