Edward Peirson Richardson, JR. (1918 – 1998) History of Neurology Edward Peirson Richardson, JR. (1918 – 1998) Richard J. Barohn, MD Gertrude and Dewey Ziegler Professor of Neurology The University of Kansas Medical Center

Edward Peirson Richardson Jr., MD (1918-1998) From a long line of HMS scholars/faculty: Father & Paternal Grandfather Chiefs of MGH surgery Mother: Clara Lee Shattuck; he was the 6th Shattuck physician & Shattuck street is where HMS is located 1939 Harvard & 1943 HMS 1944 – 1946: Served in WWII as a physician 1946: MGH Psychiatry Resident under Dr. Stanley Cobb 1947: Queens Square Neurology & Maudsley Hospital for Psychiatry Queen Square-exposed to Dr. J. Goodwin Greenfield Neuropathology 1949: MGH Asstistant to Dr. Charles Kubik in Neuropathology 1951 – 1989: Neuropathology Lab Director Worked with Adams, Miller Fisher, Castlemen, & Victor Continued to work until a few months before his death from lymphoma 1984: Bullard Professor of Neuropathology

Edward Peirson Richardson Jr., MD (1918-1998) MGH residents all did 1 year Neuropathology for many years & were trained by EPR He taught Neuropathology courses at HMS for 2nd year medical students with RD Adams, MD & Alfred Pope, MD Also taken by all Neuropathology trainees - Neurology and Path residents Frequent contributor to Pathology section of NE Journal of Medicine & CPCs Led Neuropathology teaching sessions/brain cutting during Tuesday evening conferences Neurology. 1967;17(8 Pt 2):22-5

Edward Peirson Richardson Jr., MD Major Contributions Progressive Multifocal Leukoencephalopathy Papers 1961 & 1988 Described what was then a new entity Corticobasal Degeneration. Arch Neurol 1968;18:20-33 The myelopathy of pernicious anemia: A neuropathological reappraisal. Acta Neurol Scand. 1968;44:Suppl 5:1-36 Granulomatous angiitis of the central nervous system: Protean manifestations and response to treatment. 1988; 51(9): 1126– 1133 Granulomatous angiitis of the central nervous system. Arch Neurol. 1968; 19:510-524 The neurological manifestations of systemic lupus erythematosus. Medicine. 1968 Jul;47(4):337-69 Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch Neurol. 1972;27:229-236 Adreno-leukodystrophy (Sex-Linked Schilder Disease) Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System. Arch Neurol. 1972;27:458-460 Adrenoleukodystrophy: A clinical and pathological study of 17 cases. Arch Neurol. 1975; 32:577-591 Hallervorden-Spatz syndrome. Arch Neurol. 1974 Jan;30(1):70-83 Subacute diencephalic angioencephalopathy. J Neurol Sci. 1974;22:197-210

Edward Peirson Richardson Jr., MD Major Contributions (cont.) Spinal epidural abscess. N Engl J Med. 1975 Sep 4;293(10):463-8 Hypoxic-Ischemic Leukoencephalopathy in Man. Arch Neurol. 1976;33(1):5-14 Subacute Spongiform Encephalopathy: Creutzfeldt-Jakob Disease. Brain. 1978;101(2):333-344 Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection. Neurology. 1987;37:562-569 Selective sparing of a class of striatal neurons in Huntington's disease. Science. 1985;230:561-563 Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol. 1985;44:559-577 Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology. 1988;38:341-347 Pathology of the Peripheral Nerve (1995) The Neurologic Illness of Eugene O'Neill. N Engl J Med. 2000;343:741-742

Letter Written for Dr. Barohn from EP Richardson

Pictures from Tyler Library RD Adams MD E.P. Richardson MD C Miller Fisher, MD Harvey Cushing MD

Elliot Richardson (1920-1999) Who was Elliot Richardson???? Former President of Harvard Former Secretary of State Former Attorney General EP Richardson's Father Answer: C - Former Attorney General in 1973

Elliot Richardson: What is he known for? Allowed minority students in Harvard Helped President Kennedy in Cuban Missile Crises Fired by President Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor Nothing Answer: C - Fired by Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor Also EP Richardson’s Brother