The Effect of High Salt Intake on Endothelial Function: Reduced Vascular Nitric Oxide in the Absence of Hypertension J Vasc Res 2013;50:458-467 - DOI:10.1159/000355270 Fig. 1.a Arteriolar dilation in response to iontophoretic application of ACh to the spinotrapezius muscle of mice fed a low or high salt diet, with or without L-arginine (L-Arg) supplementation. Inset: BH4 levels measured by HPLC in arterioles from animals in each group. b Arteriolar wall ethidium bromide fluorescence (an index of O2- levels) after exposure to hydroethidine in each experimental group. a, b * p < 0.05 vs. low salt groups. Adapted from Nurkiewicz et al. [24], with permission. © 2013 S. Karger AG, Basel

The Effect of High Salt Intake on Endothelial Function: Reduced Vascular Nitric Oxide in the Absence of Hypertension J Vasc Res 2013;50:458-467 - DOI:10.1159/000355270 Fig. 2. Schematic diagram illustrating cellular and subcellular events that may contribute to reduced NO bioavailability in the peripheral vasculature following high dietary salt intake. A reduction in plasma Ang II levels plays a key role in linking increased salt intake to changes in the activity of oxidant and antioxidant enzymes in the vascular wall, although the details of this linkage are not well understood. ONOO- = Peroxynitrite. © 2013 S. Karger AG, Basel