Pathophysiology of ischemia-induced acute kidney failure

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Pathophysiology of ischemia-induced acute kidney failure Pathophysiology of ischemia-induced acute kidney failure. Mild or uncomplicated medullary hypoxia results in tubuloglomerular reflex adjustments that restore medullary oxygen sufficiency at the price of diminished renal function. However, in the event of extreme renal medullary hypoxia or when associated with complicating factors such as those indicated in the figure, full-blown acute kidney failure develops. Whether acute kidney failure is reversible or irreversible depends on a balance of reparative and complicating factors. (Reproduced, with permission, from McPhee SJ et al [editors]. Pathophysiology of Disease: An Introduction to Clinical Medicine, 3rd ed. McGraw-Hill, 1999.) Source: Kidney Disease, Current Medical Diagnosis & Treatment 2017 Citation: Papadakis MA, McPhee SJ, Rabow MW. Current Medical Diagnosis & Treatment 2017; 2016 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1843/cmdt17_ch22_ef004.png&sec=135715162&BookID=1843&ChapterSecID=135715089&imagename= Accessed: October 26, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved