The relationship of angiographically defined coronary artery disease with insulin sensitivity and secretion in subjects with different glucose tolerance

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The relationship of angiographically defined coronary artery disease with insulin sensitivity and secretion in subjects with different glucose tolerance Hua Wang, MS, Bo Hu, MS, Weixin Lu, MD, Fengjing Liu, MD, Bo Feng, MD Journal of Cardiology Volume 60, Issue 5, Pages 367-371 (November 2012) DOI: 10.1016/j.jjcc.2012.06.008 Copyright © 2012 Japanese College of Cardiology Terms and Conditions

Fig. 1 Comparison of the levels of plasma glucose, insulin and C-peptide of the divided groups. Comparison of the levels of plasma glucose, insulin, and C-peptide was according to OGTT in newly diagnosed NGT (triangles), IGR (circles), and DM (cubes) groups. Solid lines indicated CAD group and dotted lines indicated non-CAD group. Values of plasma glucose, insulin, and C-reactive peptide are the mean. Compared CAD with non-CAD in NGT patients, *p<0.05, **p<0.01; compared CAD with non-CAD in IGR patients, †p<0.05, ††p<0.01; compared CAD with non-CAD in DM patients, ‡p<0.05, ‡‡p<0.01. Comparing results between CAD and non-CAD group were AUC-Glu (p=0.007), AUC-Ins (p=0.121), and AUC-Cp (p=0.223) in NGT patients; comparing results between CAD and non-CAD group were AUC-Glu (p=0.163), AUC-Ins (p=0.061), and AUC-Cp (p=0.452) in newly diagnosed IGR patients; comparing results between CAD and non-CAD group were AUC-Glu (p=0.438), AUC-Ins (p=0.073), and AUC-Cp (p=0.054) in newly diagnosed DM patients. AUC-Glu=(0.5×Glu0+Glu30+Glu60+Glu120+0.5×Glu180), AUC-Ins=(0.5×Ins0+Ins30+Ins60+Ins120+0.5×Ins180), AUC-Cp=(0.5×Cp0+Cp30+Cp60+Cp120+0.5×Cp180). NGT, normal glucose tolerance; CAD, coronary artery disease; IGR, impaired glucose regulation; DM, diabetes mellitus; OGTT, oral glucose tolerance test; AUC, area under the curve; Glu, glucose; Ins, insulin; Cp, C-peptide. Journal of Cardiology 2012 60, 367-371DOI: (10.1016/j.jjcc.2012.06.008) Copyright © 2012 Japanese College of Cardiology Terms and Conditions