Type II collagen C2C epitope in human synovial fluid and serum after knee injury – associations with molecular and structural markers of injury  N. Kumahashi,

Slides:



Advertisements
Similar presentations
Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.
Advertisements

The association between metacarpal ratio, radiographic hand and knee osteoarthritis and its progression after meniscectomy  P.T. Paradowski, L.S. Lohmander,
Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases  A. Struglics,
Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury  C.M. Haslauer,
Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis  M.S. Corbett, S.J.C. Rice,
Prolonged trauma-induced increase of inflammatory cytokines in synovial fluid after surgical reconstruction of anterior cruciate ligament ruptures compared.
Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory.
P.T. Paradowski, L.S. Lohmander, M. Englund 
J.L. Huebner, M.S., V.B. Kraus, M.D., Ph.D. 
The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes:
Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot  A. Struglics, Ph.D., S. Larsson, B.Sc., L.S.
An ARGS-aggrecan assay for analysis in blood and synovial fluid
Disability and quality of life of patients with knee or hip osteoarthritis in the primary care setting and factors associated with general practitioners'
D. J. Bechard, T. B. Birmingham, A. A. Zecevic, I. C. Jones, K. M
Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury  P. Neuman, L.E.
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor  P.S. Chockalingam, W. Sun, M.A. Rivera-Bermudez,
S. Kashyap, H. Zhang, M. Sonka  Osteoarthritis and Cartilage 
The acutely ACL injured knee assessed by MRI: changes in joint fluid, bone marrow lesions, and cartilage during the first year  R.B. Frobell, P.T., Ph.D.,
P.T. Paradowski, L.S. Lohmander, M. Englund 
Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over five years after anterior cruciate ligament rupture  A.
Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives  Y. Henrotin  Osteoarthritis and Cartilage 
Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative 
Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients  F.M. Germaschewski, C.J. Matheny, J. Larkin,
A more informed evaluation of medial compartment loading: the combined use of the knee adduction and flexor moments  K. Manal, E. Gardinier, T.S. Buchanan,
Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis  F. Bellucci,
Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis  M. Hasegawa, M.D.,
C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study  G. Engström, M.D., Ph.D.,
Health-related quality of life and costs in patients with osteoarthritis on waiting list for total knee replacement  M. Núñez, Ph.D., E. Núñez, Ph.D.,
Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation 
Measurement of matrilin-3 levels in human serum and synovial fluid using a competitive enzyme-linked immunosorbent assay  J.-B. Vincourt, P. Gillet, A.-C.
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early.
B. C. Fleming, H. L. Oksendahl, W. A. Mehan, R. Portnoy, P. D
Lisa G. Criscione, M. D. , Alan L. Elliott, M. D. , M. P. H
Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis. Results.
Knee cartilage assessment with MRI (dGEMRIC) and subjective knee function in ACL injured copers: a cohort study with a 20 year follow-up  P. Neuman, H.
Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and.
Risk factors associated with reduced work productivity among people with chronic knee pain  M. Agaliotis, M. Fransen, L. Bridgett, L. Nairn, M. Votrubec,
J. Ranstam  Osteoarthritis and Cartilage 
Y.Y. Leung, J.L. Huebner, B. Haaland, S.B.S. Wong, V.B. Kraus 
Sampling uncertainty in medical research
M. P. Brown, D. V. M. , M. Sc. , T. N. Trumble, D. V. M. , Ph. D. , J
Aggrecan fragments in the synovial fluid of osteoarthritis and juvenile idiopathic arthritis patients reveals differences in the specificity of aggrecanase.
Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis  Y. Laufer,
Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression  P.T. Paradowski, L.S. Lohmander, M. Englund 
C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis  M. Blagojevic, C. Jinks, A. Jeffery, K.P.
Joint dependent concentrations of bone alkaline phosphatase in serum and synovial fluids of horses with osteochondral injury: an analytical and clinical.
Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies  K. Michaëlsson,
Who should have a joint replacement? A plea for more ‘phronesis’
Cartilage boundary lubrication of ovine synovial fluid following anterior cruciate ligament transection: a longitudinal study  M. Atarod, T.E. Ludwig,
Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies  T.
Associations between patellofemoral joint cartilage T1ρ and T2 and knee flexion moment and impulse during gait in individuals with and without patellofemoral.
Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous.
D.J. Hunter  Osteoarthritis and Cartilage 
Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid  M.P. Brown, D.V.M., M.Sc., T.N.
A. Struglics, M. Hansson, L.S. Lohmander  Osteoarthritis and Cartilage 
S.G. Muthuri, D.F. McWilliams, M. Doherty, W. Zhang 
C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec 
Osteoarthritis year 2012 in review: biology
Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic osteoarthritis in subjects with previous.
Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method  M.
Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses  T.N. Trumble, D.V.M., Ph.D.,
Synovial fluid concentration of gremlin1 but not frizzled-related protein is increased in patients after acute knee injury  L. Zhong, J. Leijten, J. Post,
Variations in pain and function before and after total knee arthroplasty: a comparison between Swedish and Australian cohorts  M.M. Dowsey, O. Robertsson,
B. C. Fleming, H. L. Oksendahl, W. A. Mehan, R. Portnoy, P. D
Osteoarthritis year in review 2016: mechanics
S. Reichenbach, P. Jüni, E. Nüesch, F. Frey, R. Ganz, M. Leunig 
Measurement of synovial fluid volume using urea
A. Carlson, B. Bothner, R. June  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Presentation transcript:

Type II collagen C2C epitope in human synovial fluid and serum after knee injury – associations with molecular and structural markers of injury  N. Kumahashi, P. Swärd, S. Larsson, L.S. Lohmander, R. Frobell, A. Struglics  Osteoarthritis and Cartilage  Volume 23, Issue 9, Pages 1506-1512 (September 2015) DOI: 10.1016/j.joca.2015.04.022 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Synovial fluid C2C concentrations after knee injury. Samples were ordered by time after injury and divided into groups of 30–47 subjects each according to Table I, with day 0 plotted at 0.33 days (8 h) due to the logarithmic X-axis. The results are expressed as means with 95% confidence intervals compared with concentrations in the reference group (dotted line and gray area). SF, synovial fluid. Osteoarthritis and Cartilage 2015 23, 1506-1512DOI: (10.1016/j.joca.2015.04.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 A bivariate scatter plot of C2C concentrations in synovial fluid (SF) and serum from knee injured patients. All 71 subjects with available data (circles) are plotted. A regression line (solid), and a line of equality (dashed) are indicated. Osteoarthritis and Cartilage 2015 23, 1506-1512DOI: (10.1016/j.joca.2015.04.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions