The exact pathogenesis of atopic dermatitis remains a mystery

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Presentation transcript:

The exact pathogenesis of atopic dermatitis remains a mystery The exact pathogenesis of atopic dermatitis remains a mystery. Patients with the disease seem to have altered autonomic function and increased plasma histamine levels. Many have elevated levels of IgE, but some are completely normal in this respect. However, none of these observations has yet provided a basis for understanding the chronic and recurrent skin lesions of atopic dermatitis. An inherited abnormality in filaggrin expression affects barrier function and seems to be associated with this disease in some children. Source: Atopic Dermatitis, Weinberg's Color Atlas of Pediatric Dermatology, 5e Citation: Prose NS, Kristal L. Weinberg's Color Atlas of Pediatric Dermatology, 5e; 2017 Available at: https://accesspediatrics.mhmedical.com/DownloadImage.aspx?image=/data/books/1913/weinderm5_ch9_f011.png&sec=138562349&BookID=1913&ChapterSecID=138562337&imagename= Accessed: October 27, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved