Meta-Analysis of Three Randomized Trials and Nine Observational Studies Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected.

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Meta-Analysis of Three Randomized Trials and Nine Observational Studies Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Disease Jae-Sik Jang, MD, PhD, Kyu-Nam Choi, MD, Han-Young Jin, MD, Jeong-Sook Seo, MD, PhD, Tae-Hyun Yang, MD, PhD, Dae-Kyeong Kim, MD, PhD, Dong-Soo Kim, MD, PhD, Sang-Hwa Urm, MD, PhD, Jin Ho Chun, MD, PhD, Soo-Jin Kang, MD, PhD, Duk-Woo Park, MD, PhD, Seung-Whan Lee, MD, PhD, Young-Hak Kim, MD, PhD, Cheol Whan Lee, MD, PhD, Seong-Wook Park, MD, PhD, Seung- Jung Park, MD, PhD American Journal of Cardiology Volume 110, Issue 10, Pages 1411-1418 (November 2012) DOI: 10.1016/j.amjcard.2012.06.051 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Flow diagram demonstrating inclusion/exclusion process for studies incorporated in final analyses. BMS = bare-metal stent. American Journal of Cardiology 2012 110, 1411-1418DOI: (10.1016/j.amjcard.2012.06.051) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Forest plot of odds ratio for mortality after treatment for unprotected left main coronary artery disease in patients treated with drug-eluting stents versus coronary artery bypass grafting stratified according to study design. CUSTOMIZE = Customized Strategy for Left Main Revascularization; M-H = Mantel–Haenszel; MAIN-COMPARE = Revitalization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization. American Journal of Cardiology 2012 110, 1411-1418DOI: (10.1016/j.amjcard.2012.06.051) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 3 Forest plot of odds ratio for composite end points in patients treated with drug-eluting stents versus coronary artery bypass grafting. Composite end points were mortality, myocardial infarction, or stroke. Abbreviations as in Figure 2. American Journal of Cardiology 2012 110, 1411-1418DOI: (10.1016/j.amjcard.2012.06.051) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 4 Forest plot of odds ratio for target vessel revascularization in patients treated with drug-eluting stents versus coronary artery bypass grafting. Abbreviations as in Figure 2. American Journal of Cardiology 2012 110, 1411-1418DOI: (10.1016/j.amjcard.2012.06.051) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 5 Funnel plot of composite end point of death, myocardial infarction, or stroke indicates the existence of publication bias with an asymmetrical funnel plot in the direction favoring coronary artery bypass grafting. Also depicted are hypothetical missing studies by the trim-and-fill method (open circles). American Journal of Cardiology 2012 110, 1411-1418DOI: (10.1016/j.amjcard.2012.06.051) Copyright © 2012 Elsevier Inc. Terms and Conditions