Research Funding

FY1992 – FY2015 NIH Extramural Awards to Top Local Independent Hospitals Total Awards ($ millions) MGH BWH UPDATED

MGH Total Research Revenue Trend (Including Other Science) MGH combined research has grown at a compounded annual growth rate of 7.4% between FY2000 and FY15. The 5-year moving average annual growth has decreased from 7.1% in FY10 to 4.2% in FY15; the FY14-FY15 growth was 5.3%, with increases across every sponsor category. Direct & Indirect Research Expenditures ($ 000’s) UPDATED Other science encompasses research support functions such as animal facilities, cores, and exchange accounts 50% 43%

MGH Research by Sponsor FY15 Direct and Indirect Revenues $800,206,486 1% from 2014, 7% from 2012 UPDATED We are up from $760M in FY14 - primarily driven by an increase in endowment and gifts, Note: Other Gov't includes Other Federal and State/Local Note: Other Gov't includes Other Federal and State/Local

MGH Research by Department FY15 Direct and Indirect Revenues $800M (Shown in $Millions) UPDATED Notes: 1- Expenditures include ARRA funding and Other Science 2- Surgery includes Pediatric Surgery, Oral Surgery and Urology 3- Other includes Administrative Departments

Proposals FY15 vs. FY14 4,373 proposals submitted in FY15, up 10% versus FY14 Fiscal Year DHHS Foundations Industry/ Corporate Non-Profit Other Federal All Other Sponsors Total 2014 1,018 651 448 1,277 173 407 3,974 2015 1,160 635 563 1,500 150 365 4,373 Difference 142 (16) 115 223 (23) (42) 399 % Change 14% -2% 26% 17% -13% -10% 10% Note: All Other Sponsors include Internal, Miscellaneous, and state/local sponsors. Excludes confidentiality agreements.

New Award Trends MGH has the highest number and amount of new awards of any institution within Partners. Although FY14 was an exceptionally good year, our new award amounts for FY15 still surpass that of FY12 & FY13 Note: -New award volumes are based on the number of parent proposal awards. -New award amounts include total budget amounts for all years of project. PHS, Research Analytics. Source: Micro Strategy

NIH Funding Market Share Trends MGH accounts for 1.6% of the NIH Budget BWH accounts for 1.5% of the NIH Budget Partners overall accounts for 3.2% of the NIH Budget Our share is increasing: FY07 1.3%; FY13 1.5%; FY15 1.6% Source: NIH Funding Report, US. Department of Health and Human Services

FY15 NIH Extramural Awards Ranking: All Institutions ORGANIZATION AWARDS FUNDING 1 JOHNS HOPKINS UNIVERSITY 1235 $584,714,172 2 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 1223 $560,409,410 6 3 UNIVERSITY OF MICHIGAN 1059 $453,368,007 4 UNIVERSITY OF PENNSYLVANIA 1094 $453,359,803 5 UNIVERSITY OF WASHINGTON 896 $434,224,865 UNIVERSITY OF PITTSBURGH AT PITTSBURGH 953 $430,310,349 8 7 STANFORD UNIVERSITY 929 $422,361,283 9 UNIVERSITY OF CALIFORNIA SAN DIEGO 841 $388,697,641 UNIV OF NORTH CAROLINA CHAPEL HILL 874 $379,585,711 10 WASHINGTON UNIVERSITY 823 $378,098,015 12 11 UNIVERSITY OF CALIFORNIA LOS ANGELES 860 $370,715,745 14 DUKE UNIVERSITY 740 $362,975,831 13 YALE UNIVERSITY 864 $352,512,800 MASSACHUSETTS GENERAL HOSPITAL 771 $351,565,758 15 BRIGHAM AND WOMEN'S HOSPITAL 539 $333,214,883 16 COLUMBIA UNIVERSITY HEALTH SCIENCES 805 $331,381,051 18 17 EMORY UNIVERSITY 679 $311,143,869 VANDERBILT UNIVERSITY 755 $303,248,528 19 UNIVERSITY OF WISCONSIN-MADISON 617 $270,626,069 22 20 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 510 $265,532,222

FY15 NIH Ranking: Independent Hospitals ORGANIZATION AWARDS FUNDING 1 MASSACHUSETTS GENERAL HOSPITAL 771 $351,565,758 2 BRIGHAM AND WOMEN'S HOSPITAL 539 $333,214,883 3 CHILDREN'S HOSPITAL BOSTON 319 $137,431,827 4 DANA-FARBER CANCER INST 220 $125,295,828 5 CHILDREN'S HOSP OF PHILADELPHIA 202 $114,023,148 6 BETH ISRAEL DEACONESS MEDICAL CENTER 236 $112,741,707 7 CINCINNATI CHILDRENS HOSP MED CTR 257 $98,324,805 8 ST. JUDE CHILDREN'S RESEARCH HOSPITAL 94 $66,612,466 9 NEW YORK STATE PSYCHIATRIC INSTITUTE 93 $44,789,229 12 10 CEDARS-SINAI MEDICAL CENTER 95 $41,464,366 11 SEATTLE CHILDREN'S HOSPITAL 84 $38,150,472 16 NATIONAL JEWISH HEALTH 56 $35,256,665 13 BOSTON MEDICAL CENTER 78 $30,632,865 15 14 ROSWELL PARK CANCER INSTITUTE CORP 67 $28,371,593 MCLEAN HOSPITAL 83 $26,164,845 17 RHODE ISLAND HOSPITAL $24,289,073 TUFTS MEDICAL CENTER 43 $22,453,135 18 CHILDREN'S HOSPITAL OF LOS ANGELES 48 $22,263,973 19 MASSACHUSETTS EYE AND EAR INFIRMARY 42 $20,663,625 46 SPAULDING REHABILITATION HOSPITAL $1,337,483

Support for Researchers

Faculty Support Special Grants Program for Faculty Goodman Award: 1 @ 300K Martin Prizes (basic/clinical): 2 @ 100K Claflin Awards: 5 @ $100K CDI Physician Scientist Awards: 2 @120K Awarding 3 in 2016 Postdoctoral Fellowships Tosteson and Fund for Medical Discovery (FMD) Awards 22 Awards @ 40K each Clinical Research FMD – 4 awards @ $40K ECOR Institutional Support For Shared Instrumentation Grant (SIG) applications FY15 budget – $500,000 Just awarded a third MAO award this year

Faculty Support (continued) Interim Support Fund (ISF) Provides funding to bridge programs with grant scores that are good but are not fundable The number of worthy applications has increased as the pay line at NIH has decreased NIH now commonly does not fund the first competing submission (the ‘A’) but funds the second (‘A1’) creating a situation where funding gaps are becoming the norm In FY15, we awarded $7.6M to 87 investigators --- “Updates to Program” slide deleted from Oct 2015 slide deck --- Increased interim support from $50,000 to $75,000 Additional ISF funds available **under exceptionally difficult circumstances** A maximum of $150,000 in total extra funds This extra support will be sourced 50:50 with Dept $150,000 ($75K base + $75K additional) from ECOR $ 75,000 sourced from Department $225,000 maximum total award

Return on Investment ROI = Gain from Investment – Cost of Investment ECOR Grants NIH Grants   Grants Total ECOR Awarded Total NIH Awarded ROI Formulaic 270 $16,905,500 156 $259,790,332 14:1 Deliberative 368 $25,475,263 118 $179,494,823 6:1 Total 638 $42,380,763 274 $439,285,155 9:1 ISF Awards and NIH Funds Received from 2006 – March 2016 9-3-10 revised version with added materials per Slavin request

ECOR Administered Support Programs The MGH Research Scholars The MGH Research Institute Chair MGH-MIT Strategic Partnership Limited Submissions & Institutional Nominations

MGH Research Scholars Launched in 2011 Goal: Support outstanding MGH investigators doing fundamental, translational and clinical research Award: $100K per year for five years May 2011 5 Research Scholars (of 115 applicants) May 2012 8 Research Scholars (of 98 applicants) March 2013 7 Research Scholars (of 81 applicants) March 2014 8 Research Scholars (of 95 applicants) March 2015 8 Research Scholars (of 77 applicants) March 2016 6 Research Scholars (of 91 applicants) 42 Scholars to date!

2016 MGH Research Scholars Caroline Burns, PhD Assistant Professor, Cardiology (CVRC) “Barriers to Mammalian Heart Regeneration”   Jacob Hooker, PhD Assistant Professor, Martinos Center “Visualizing Chemical Dysfunction in the Human Brain” J. Keith Joung, MD, PhD Professor, Pathology “Advancing CRISPR-based Genome and Epigenome Editing Technologies”

2016 MGH Research Scholars Cammie Lesser, MD, PhD Associate Professor, Infectious Disease “Designer probiotics for the treatment of infection, inflammation and cancer”   Filip Swirski, PhD Assistant Professor, Center for Systems Biology “Macrophages in Physiology, Inflammation, and Metabolism” Seok-Hyun (Andy) Yun, PhD Associate Professor, Wellman Center for Photomedicine “Barcoding cells with laser mitochondria”

The First MGH Research Institute Chair Announcing the Bernard and Mildred Kayden Endowed MGH Research Institute Chair We are thrilled to announce a significant milestone for the Massachusetts General Hospital Research Institute. Thanks to a generous and visionary gift from The Kayden Foundation, we have established the first endowed chair within the Research Institute to foster and accelerate cutting-edge innovation at Mass General in perpetuity.   Mass General frequently establishes chairs to honor physicians in specific specialties. However, the Research Institute’s endowed chairs are intended to honor outstanding investigators whose work may intersect multiple disciplines and departments, and whose work we believe will play an important role in preventing disease and improving patient care for generations to come.   This newly endowed position will be named the Bernard and Mildred Kayden Endowed MGH Research Institute Chair. The Kayden Foundation was motivated to make this gift by what it sees as “the silo-busting aspects of the Research Institute” and the difference that hard funding can make in the work of outstanding scientists.   The Research Institute Steering Committee solicited nominations from all of the Mass General’s chiefs and center directors. An impressive list of more than 40 worthy scientists was generated, and the Research Institute Steering Committee chose Bradley E. Bernstein, MD, PhD, as the inaugural incumbent of the Bernard and Mildred Kayden Endowed MGH Research Institute Chair.   Dr. Bernstein is a pathologist at Mass General, an Institute Member of the Broad Institute of Harvard and MIT, and a professor in the department of pathology at Harvard Medical School. Dr. Bernstein leads a vibrant research group within an interactive academic community. He has successfully directed diverse and pioneering projects in genomics, technology development, chromatin, stem cell and cancer biology. Dr. Bernstein’s research group innovates and applies genomic tools to study chromatin and epigenetic gene regulation in stem cells and tumor models. These studies have advanced the understanding of gene regulatory elements, chromatin states and epigenetic mechanisms in development and disease.   Dr. Bernstein’s work has received numerous awards and recognitions that have included the Mass General Howard M. Goodman Fellowship in 2006, a Howard Hughes Medical Institute Early Career Scientist award in 2009, the Mass General Martin Prize for Basic Science in 2012, and the Paul Marks Prize for Cancer Research from Memorial Sloan Kettering Cancer Center in 2015. He also received a coveted American Cancer Society Research Professorship in 2015. Dr. Bernstein has authored over 100 peer-reviewed publications.   We are excited to name Dr. Bernstein as the first incumbent of the Bernard and Mildred Kayden Endowed MGH Research Institute Chair and we are confident that his commitment to scientific inquiry will help to advance research in the field of epigenetics for years to come. Please join us in congratulating Dr. Bernstein.   Bradley E. Bernstein, MD, PhD