A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system Wing-Chi.

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Presentation transcript:

A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system Wing-Chi Cheng, Tsan-Sang Yau, Ming-Kei Wong, Lai-Ping Chan, Vincent King-Kuen Mok Forensic Science International Volume 162, Issue 1, Pages 95-107 (October 2006) DOI: 10.1016/j.forsciint.2006.04.019 Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Scheme 1 Schematic diagram showing the workflow of the urinalysis system. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 The representative selective ion chromatograms of urine spiked with standards at cut-off concentrations. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 (a) An example of an “semi-quantitative summary sheet (page 1)” and (b) “semi-quantitative summary sheet (page 2)” for benzodiazepines. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 A typical “library search sequence” for “positive” in semi-quantitative analysis found in the sequence 0721MKAO_T generated by the macro-program. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 (a) An example of “library search summary sheet (page 1)” and (b) “library search summary sheet (page 2)” for all benzodiazepines. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 A hardcopy of the data transferred from macro-program to central database. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 An example of the compiled report for sample, UCN 3639, which included selective ion chromatograms, semi-quantitation report and MS/MS matching data. Forensic Science International 2006 162, 95-107DOI: (10.1016/j.forsciint.2006.04.019) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions