Development of Harvard Catalyst Imaging Consultation Service C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD February 27,2009 http://catalyst.harvard.edu

Technology and Expertise IT Structure Why be a consultant ? Agenda Harvard Catalyst Imaging Consortium Technology and Expertise IT Structure Why be a consultant ? Educational Opportunities Contact

Harvard Catalyst: The Basics We are a pan-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 2

National Effort in C/T Research We are supported by a Clinical and Translational Science Award (CTSA) awarded by the NIH’s National Center for Research Resources (NCRR) in May 2008, as well as commitments from many of our partner institutions. We are a member of NCRR’s CTSA Consortium (see map), a group of 38 academic health centers nationwide with NIH-supported programs for clinical and translational research. Source: http://www.ctsaweb.org/ Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium 3 3

Institutions participating in Harvard CTSC  Academic Healthcare Centers Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Specialty Hospitals and Institutes Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 4

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison 5

Mission of the Imaging Consortium Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment. 6

Harvard Catalyst website Access to resources and profiles http://catalyst.harvard.edu 7

Image Consortium Consultation Service Access to the consultation service: http://catalyst.harvard.edu/home.html 8

Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 9

XNAT-PACS-i2b2 Integration IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer. 10

XNAT-PACS-i2b2 Integration Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers XNAT Enterprise PACS PACS Project Management Annotating Genomic Data #2 File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Slicer: Data visualization analysis Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 11 i2b2 HIVE

Becoming an Imaging Consultant Potential benefits of being an active collaborator: Good framework for research Research opportunities through collaborations Meeting experts out of radiology Networking with imaging cores outside of Boston Example: standardization of physiologic monitoring system for fMRI 12

Educational Opportunities proposal Nanocourse: Imaging 101 More advanced classes: Tumor metrics Radiation safety issues for IRB submission Hands-on classes on data analysis Imaging perfusion Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt 13

http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC