Regional generation of free oxygen radicals during cardiopulmonary bypass in children Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri.

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Presentation transcript:

Regional generation of free oxygen radicals during cardiopulmonary bypass in children Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri Leijala, MDa, Heikki Sairanen, MDa, Kari O. Raivio, MDa, Per Venge, MDb, Sture Andersson, MDa c The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 3, Pages 768-773 (September 1995) DOI: 10.1016/S0022-5223(95)70110-9 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < 0.001 versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < 0.001 versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < 0.001 versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < 0.001 versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < 0.001 versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Plasma lactoferrin (LF) and myeloperoxidase (MPO) concentration differences between arterial and venous lines of the oxygenator. †p < 0.05 and ††p < 0.01 for arterial versus venous line (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 768-773DOI: (10.1016/S0022-5223(95)70110-9) Copyright © 1995 Mosby, Inc. Terms and Conditions