Pharmaceutical Particles

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Presentation transcript:

Pharmaceutical Particles

Taylor Cone When a sufficiently high voltage is applied to a liquid droplet, the body of the liquid becomes charged, and electrostatic repulsion counteracts the surface tension and the droplet is stretched; at a critical point a stream of liquid erupts from the surface. This point of eruption is known as the Taylor cone. Taylor cone Jet Fibers

Electro-hydrodynamic Atomization Process (Hydrospraying) Using electric field to break liquid drops into fine droplets Vn Vr Vacuum pump Filter Particles : the trace of protective Nitrogen; : solvent with polymer & drugs; : volatilized solvent; : collected polymer & drug particles; Vn : high voltage used to break liquid drops; Vr : high voltage applied to metal hoop; https://www.youtube.com/watch?v=ImLdSIGdkGM

Electrospinning https://www.youtube.com/watch?v=87uRQ7KwbB0 https://www.youtube.com/watch?v=JECE_6iK4i0

Supercritical AntiSolvent setup TC PI V2 V1 V3 F2 F1 C2 CO2 C1 https://www.youtube.com/watch?v=fKpP0vwW68Q https://www.youtube.com/watch?v=Rh2NiuFlpYg

U1 P1 P2 TC PI V2 V1 V3 F2 F1 C2 CO2 C1

Conclusion Different methods of producing drugs (particles) How particle sizes are controlled in each production method Gam-Sia-Hamida

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