Central dogma: from genome to proteins II: Translation

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Central dogma: from genome to proteins II: Translation Haixu Tang School of Informatics

The genetic code

Reading frames

tRNA

Unusual nucleotides

Amino acid activation

Editing of tRNA activation

tRNA matching

Peptide synthesis

Head vs. tail polymerization

Ribosomes

Ribosome structures

Ribosome structure

A possible reaction mechanism

Translation initiation

Structure of a typical bacterial mRNA molecule

Translation termination

Simultaneous translation

The rescue of a bacterial ribosome

Frameshift

Creation of mature proteins

Co-translational folding

Protein folding

Molecular chaperones

Monitoring protein quality

Protein degragation

Ubiquitin

Protein aggregation

Protein cycle in eukaryotic cell

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