Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting A phase III trial of neoadjuvant chemotherapy with or without anthracyclines in the presence of dual HER2-blockade for HER2-positive breast cancer: the TRAIN-2 study (BOOG 2012-03) Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Background Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Aim Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting TRAIN-2 study design Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Statistical considerations Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Patient disposition Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Baseline characteristics Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Primary endpoint: pCR breast & axilla Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

pCR by hormone receptor status Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Subgroup analysis Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Treatment exposure Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Grade ≥3 hematological adverse events Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Grade ≥3 non-hematological adverse events Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Cardiac safety Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Discussion Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Conclusions Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting

Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting Acknowledgements Presented By Mette Van Ramshorst at 2017 ASCO Annual Meeting