Stress Tau Pathology & Alzheimer’s Disease 11307110112 xiao zitian.

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stress Tau Pathology & Alzheimer’s Disease 11307110112 xiao zitian

GCs (glucocorticoids) TAU hyperphosphorylation Key words: GCs (glucocorticoids) 1 TAU hyperphosphorylation 2 Aβ (Amyloid β) 3

Method & Material Animal Stress model Infusion Behavioral Immunoblot Age:14 months Standard environmental conditions Animal Daily Chronic stressors: 1.hypertonic saline; 2.overcrowding(1 h); 3.confined environment (30 min); 4.vibrating/rocking platform (1 h) Stress model Intracerebroventri-cular infusions (solubilized A β 1-40 or vehicle) Sg: subcutaneous GC injections Infusion 1.Spatial reference memory(tested by Morris water maze) 2.Assessment of reversal learning(collected by video tracking system) Behavioral test 1.Western blot analysis 2.immunocytochemistry Immunoblot

Results & Discussion Sotiropoulos I, Catania C, Pinto L G, et al. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits[J]. The Journal of Neuroscience, 2011, 31(21): 7840-7847. 1.induce ：chronic stress & abnormal hyperphosphorylation 2.overexpression: stress and GCs increased the expression of a number of kinases in the hippocampus and PFC of animals 3.activator: stress and/or GC activated pERK1/2, pGSK3, p35 (the cdk5 activator),pJNK, and CaMKII in the hippocampus and PFC