More complex considerations of receptor signaling. A

Slides:

Advertisements

Similar presentations

CMS-1500 Outpatient Medical Service Claim Form

Advertisements

ACLS algorithm for bradycardia

Synthesis and receptor interactions of active peptides generated by the kallikrein-kinin and renin-angiotensin systems. Bradykinin is generated by the.

Source: Saseen JJ, MacLaughlin EJ. Hypertension

A, Diagnosis of clinical severity (mild, moderate, severe) of hemophilia is based on in vitro coagulant activity as shown. B, Distribution of severe and.

Spectrum of different types of human gene mutations logged in Human Gene Mutation Database as of September 13, 1998 ( Source: The.

Model for regulation of the Ras p21 product and for the GTPase-activating protein (GAP) as a downstream effector and regulator of ras activity. Ras is.

(Adapted, with permission, from Fagin JA

The tracing shown was observed at EP study in a young man without evidence of heart disease. What is the likely mechanism of tachycardia for both the narrow.

Some general features of immune responses. A

A. Mechanism of action of aspirin

3D and 4D ultrasound volume ultrasound can obtain image planes and provide depth far beyond the capability of 2D ultrasound. Source: VOLUME SONOGRAPHY:

Dixon LB, Perkins B, Calmas C

Action of histamine and antihistamines on the H1 receptor

Actions of Leukotriene Antagonists and Corticosteroids

ACLS algorithm for bradycardia

ACLS algorithm for asystole

Wong-Baker FACES pain scale (Wong-Baker FACES Foundation (2015)

The woundEL LVMPC device delivers the same signal previously used in clinical wound healing studies performed in the United States and Germany that reported.

Pathophysiology of esophageal reflux disease

Virtual integration involves contractual links between HMOs and physician groups, hospitals, and other provider units. Source: How Health Care Is Organized—II:

The lymphocyte markers that distinguish the various stages of B-cell differentiation are shown. Markers that are expressed on the cell surface are indicated.

Delegation guidelines.

Pathogenesis of bone diseases in chronic kidney disease

Schematic representation of the DTDST protein

A simplified diagram of smooth muscle contraction and the site of action of calcium channel-blocking drugs. Contraction is triggered (red arrows) by influx.

(Reprinted by permission from Macmillan Publishers Ltd

A chamber designed to treat multiple patients

Proposed sites of action of current multiple sclerosis (MS) treatments

Upregulation of the cAMP pathway as a mechanism of opiate tolerance and dependence. Opiates acutely inhibit the functional activity of the cAMP pathway.

C. Asynchronous background input alone drives a low level of firing even in the absence of any signaling input, as seen by the two spikes that occur in.

PICC line thrombus (arrow) with 2D (A) and 3D (B) imaging.

Nine patterns of inflammatory skin disease. (See also Table 8–1.)

The PKD1 and PKD2 gene products are integral transmembrane proteins

Diagnostic algorithm for normocytic anemia.

Receptor occupancy and clinical response for antipsychotic agents

The amine hypothesis of major depression

Using the prosthesis as an assisting hand

The LifeStat system is an example of a piston compression device

Structures of antiestrogens and aromatase inhibitors

Oral contraceptive pill hormonal components

Limbic regions involved in emotion and mood. A

Neural reward circuits for various drugs (cocaine, amphetamines, opiates, nicotine, and ethanol) in a sagittal section of rat brain. A limbic–extrapyramidal.

Hypothetical mechanism of ketamine’s antidepressant effects

Ligand- and signal-activated transcription factors (represented by the round and the rectangular symbols, respectively) can bind to the promoter regions.

Direct and indirect action of free electrons created by ionizing radiation. (Reproduced, with permission, from Hall EJ, Giaccia AJ. Radiobiology for the.

Scaphoid fracture. A. Scaphoid fracture nonunion. B

Model depicting the cycling of REP

Ca2+ and phosphatidylinositol second messenger systems

Activation of protein kinases. A

Midsagittal section through the brain of a patient with a brain stem tumor. Histologic findings showed the tumor to be an ependymoma. Source: Discussion.

Model of the interaction of T3 with the T3 receptor

Rodin, “The Kiss” (545 x 800). Accessed at

A model of the interaction of a steroid, S (eg, cortisol), and its receptor, R, and the subsequent events in a target cell. The steroid is present in the.

Regulation of gating in ion channels

This defibrillator device has been set to synchronized “SYNC” mode

FISH of glioblastoma. This interphase nucleus from a glioblastoma contains three chromosome 7 centromere signals (dark) and one centromere 10 signal (light).

An emerging molecular “parts list” for schizophrenia

Principle of ion exchange in drug delivery systems

A model for the role of ALK-1 and endoglin in normal angiogenesis

Overview of the TGF-β signaling pathway

The JAK-STAT signal-transduction pathway

Number of uninsured persons in the United States, 1980 to 2014 (U. S

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Volume 147, Issue 5, Pages (November 2011)

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Vascular Endothelial Growth Factor (VEGF) Pathway

Selective Estrogen Receptor Modulators and Phytoestrogens: New Therapies for the Postmenopausal Woman Lorraine A. Fitzpatrick, MD Mayo Clinic Proceedings

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ.

Presentation transcript:

More complex considerations of receptor signaling. A More complex considerations of receptor signaling. A. Several types of receptors have been shown to form dimers, with the receptor dimer responding to different ligands (agonists, antagonists, or inverse agonists) compared with the receptor monomers. B. Other receptors exhibit ligand-directed signaling. In the example shown, one class of agonist at the serotonin 5HT2A receptor activates Gq with downstream signaling via phospholipase C, whereas another class of agonist triggers the receptor to activate Gi/o (and possibly other G proteins) with downstream signaling via arachidonic acid metabolites. Source: Basic Principles of Neuropharmacology, Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 3e Citation: Nestler EJ, Hyman SE, Holtzman DM, Malenka RC. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 3e; 2015 Available at: https://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1204/nes003_fig_01-07.png&sec=72648741&BookID=1204&ChapterSecID=72648697&imagename= Accessed: October 28, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved