Nucleophilic Addition to the Carbonyl Group

Slides:

Advertisements

Similar presentations

Oxidation-Reduction Reactions (Ox-Redox)

Advertisements

Oxidation of alcohols, aldehydes and ketones

Aldehyde and Ketone Reactions

Aldehid dan Keton.

Aldehydes, ketones. Required background: Structure of alkenes Nucleophilic substitution S N 1, S N 2 Essential for: 1. Carboxylic aids and their derivatives,

Goals for the Day… Epoxide ring openings Aldehydes & ketones Naming Physical Properties Reactions.

Preparation And Properties Of Aldehydes and Ketones Prepared By Prerna Gupta KV Samba.

Ketones, Aldehydes CH21 PS CLASS. Recall the many times we’ve synthesized these! I command thee. Oxidation of R-OH – (Periodinane, CrO 3 /Na 2 Cr 2 O.

Organic Chemistry Reviews Chapter 16 Cindy Boulton April 5, 2009.

Alcohol Reactions. Conversions to esters (Acetate Lab) Reactions with hydrogen halides Acid-catalyzed hydrations.

Reactions for Exam (you will have the reducing agent chart on exam): Everything from 241a (epoxidations, halides from alcohols, ether synthesis) Electrophilic.

C HAPTER 13: A LDEHYDES AND K ETONES. Before you can learn about aldehydes and ketones, you must first know something about the nomenclature of carboxylic.

74 Chapter 15: Alcohols, Diols, and Thiols 15.1: Sources of Alcohols (please read) Hydration of alkenes (Chapter 6) 1. Acid-catalyzed hydration 2. Oxymercuration.

Chapter 9: Aldehydes and Ketones The Civet Cat is the original source of civetone, a sweet and pungent ketone used as a fixative in perfumery.

Industrial Sources of Alcohols: Carbon Monoxide and Ethene 8-4 Methanol is commercially synthesized from synthesis gas, a mixture of CO and H 2 : A change.

ORGANIC CHEMISTRY. Uniqueness of carbon Can form multiples bonds to itself and with other atoms of other elements The strength of the C-C and C-H bond.

Aldehydes and Ketones. Before you can learn about aldehydes and ketones, you must first know something about the nomenclature of carboxylic acids since.

I. Organometallic Reagents = carbon-metal bonds

II. Reactions of Alcohols A. Oxidation B. Formation of alkyl halides C. Formation of tosylates D. Dehydration E. Formation of esters.

Alcohols. Complete Combustion of Alcohols IB Chemistry SL CC23E83D555 Oxidation reactions.

Aldehydes and Ketones Chapter 5. Aldehydes and Ketones Functional group is O Functional group is O The carbonyl l l group C group C Aldehyde = Carbonyl.

Chapter 17 Aldehydes and Ketones I.Properties and Names of Aldehydes and Ketones A.Nomenclature 1)Carbonyl groups are the highest priority functional group.

Oxidation of Alcohols A Peer-Assisted Learning Demonstration.

Aldehydes and Ketones. II. Oxidation and Reduction; Synthesis Chapter 17.

Dehydration of Alcohols to form Ethers

12 Chemistry 2.5 organic chemistry CR 07 Alcohols Alcohols have the function group –OH General formula: C n H 2n+1 OH or C n H 2n+2 O.

1 Aldehydes and Ketones. Carbonyl compounds The compounds occur widely in nature as intermediates in metabolism and biosynthesis They are also common.

PREPARATION OF ALDEHYDES AND KETONES CLASS XII. PREPARATION.

Reactions of Alcohols Susan F. Hornbuckle Associate Professor of Chemistry Clayton State University.

Chapter 12: Alcohols from Carbonyl Compounds CH 12-1 Alcohol RedOx Oxidation (loss of H) of alcohols to form carbonyls Reduction (gain of H) of carbonyls.

1 Friedel-Crafts: Control Problems Multiple alkylations can occur because the first alkylation adds electron density and makes the ring more reactive:

Aldehydes and Ketones. Before you can learn about aldehydes and ketones, you must first know something about the nomenclature of carboxylic acids since.

1 Figure 18.1 Five examples of electrophilic aromatic substitution.

Aldehydes/Ketones: Nucleophilic Addition Reactions.

Chapter 9 Aldehydes and Ketones: Nucleophilic Addition Reactions

Carbanions | — C: – The conjugate bases of weak acids,

Aldehydes and Ketones.

Hydrolysis of Acid Derivatives

Reactions: OXIDATION & REDUCTION ROHAZITA BAHARI

Acyl chlorides.

Synthesis of Ketones From Acids

Chapter 13: Aldehydes and Ketones

Aldehydes and Ketones.

Reaction Schematic Reduction Hydration Carbonyl Alkene Alcohol

13.7 Aldehydes and Ketones.

Chapter 9: Aldehydes and Ketones

Section 2c CHEM 222 Coursepack

Properties Nomenclature Preparation Reactions Synthesis

Examples of Carbocation Formation

Recognise and name aldehydes and ketones.

الألدهيدات و الكيتونات

Preparation of ethanol

Chem. 108 Aldehydes and Ketones Chapter 9.

Drill and Practice: Reactions of Alcohols

Acyl chlorides.

Friedel-Crafts Acylation of Benzene

Chapter 20 Introduction to Carbonyl Chemistry; Organometallic Reagents; Oxidation and Reduction.

Fundamentals of Organic Chemistry

Alcohols R-O-H Classification CH3, 1o, 2o, 3o Nomenclature:

Reversible addition at a carbonyl group

Fundamentals of Organic Chemistry

Properties Nomenclature Preparation Reactions Synthesis

Fundamentals of Organic Chemistry

Fundamentals of Organic Chemistry

Fundamentals of Organic Chemistry

ALDEHYDES AND KETONES.

Phenols 340 Chem 1st 1439.

Fundamentals of Organic Chemistry

Presentation transcript:

Nucleophilic Addition to the Carbonyl Group Aldehydes and Ketones Nucleophilic Addition to the Carbonyl Group

A. Aldehyde 1. Oxidation of primary alcohols PDC: Pyridinium Chlorochromate C5H5NHCrO3Cl

2. Reduction of acid chloride 3. Oxidation of methylaromatics Aromatic aldehydes only!

K2Cr2O7, special cond. or C5H5NHCrO3Cl 1o alcohol Ar-CH3 Aromatic only 1. CrO3 /(AcO)2O 2. H2O/H+ aldehyde acid chloride LiAlH(O-t-Bu)3

B. Ketone 1. Oxidation of secondary alcohols 2. Friedel-Crafts acylation Aromatic ketones (phenones) only

3. Coupling of RCOCl and R2CuLi

2o alcohol K2Cr2O7, etc. ketone acid chloride + ArH AlCl3 acid chloride + R2CuLi