Volume 137, Issue 6, Pages (June 2010)

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Volume 137, Issue 6, Pages 1354-1361 (June 2010) Advantages of Endurance Treadmill Walking Compared With Cycling To Assess Bronchodilator Therapy Xiaolei Zhang, MD, PhD, Laurie A. Waterman, MS, Joseph Ward, RCPT, John C. Baird, PhD, Donald A. Mahler, MD, FCCP CHEST Volume 137, Issue 6, Pages 1354-1361 (June 2010) DOI: 10.1378/chest.09-2470 Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 1 Diagram of enrollment, allocation, follow-up, and analysis of patients. CHEST 2010 137, 1354-1361DOI: (10.1378/chest.09-2470) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 2 Mean and SD values for FEV1 (A) and for FRC (B) at baseline (left vertical bar for each condition) and at 30 (middle vertical bar for each condition) and 120 min (right vertical bar for each condition) after inhalation of the study medication prior to treadmill and cycle exercise. AFR = arformoterol; FRC = functional residual capacity; NS = nasal saline. *P < .05 compared to baseline values. CHEST 2010 137, 1354-1361DOI: (10.1378/chest.09-2470) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 3 Individual values for endurance time during constant-load cycle and treadmill exercise tests after inhalation of the study medication. There were significant increases in endurance exercise time with ARF compared with NS with cycle (Δ: 110 ± 219 s) and with treadmill (Δ: 157 ± 286 s) exercise. *P = .038; †P = .024. See Figure 2 legend for expansion of abbreviations. CHEST 2010 137, 1354-1361DOI: (10.1378/chest.09-2470) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 4 Individual values for differences (rest minus end-exercise) in oxygen saturation (Spo2) during constant-load cycle and treadmill exercise tests after inhalation of the study medication. The magnitude of desaturation was unchanged with ARF compared with NS during cycle exercise (P = .74), but was significantly attenuated during treadmill exercise (P = .012). *P = .012. See Figure 2 legend for expansion of abbreviations. CHEST 2010 137, 1354-1361DOI: (10.1378/chest.09-2470) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 5 Individual values for the regression slope of breathlessness and time during constant-load treadmill (A) and cycle (B) exercise after inhalation of ARF and NS. Paired t tests showed a significant difference between ARF and NS for treadmill exercise (P = .007), but not for cycle exercise (P = .67). n = 19 as one patient did not provide ratings at each visit. See Figure 2 legend for expansion of abbreviations. CHEST 2010 137, 1354-1361DOI: (10.1378/chest.09-2470) Copyright © 2010 The American College of Chest Physicians Terms and Conditions